Results 91 to 100 of about 1,445,190 (422)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Methodology of the primary data reconstruction of single pipe heating systems/Vienvamzdžių šildymo sistemų pirminių duomenų nustatymo metodika

Journal of Civil Engineering and Management, 1999
The majority of dwellings in Lithuania are situated in blocks of flats. The dwellings were built after World War II and they are heated by single pipe central heating systems, connected to district heating.
Edvardas Tuomas, Saulius Neverbickas
doaj   +1 more source

Passive house ventilation strategies: demand control? [PDF]

, 2009
Since insulation levels in a passive house context are very high, energy losses trough ventilation are of relatively high importance in the total energy balance of a passive house concept.
Janssens, Arnold, Laverge, Jelle
core   +1 more source

Extracorporeal support for patients with acute respiratory distress syndrome. [PDF]

, 2014
Extracorporeal membrane oxygen (ECMO) has been used for many years in patients with life-threatening hypoxaemia and/or hypercarbia. While early trials demonstrated that it was associated with poor outcomes and extensive haemorrhage, the technique has ...
Finney, SJ
core   +3 more sources

Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2019
Importance Daily spontaneous breathing trials (SBTs) are the best approach to determine whether patients are ready for disconnection from mechanical ventilation, but mode and duration of SBT remain controversial.
C. Subirà, G. Hernández, A. Vázquez, R. Rodríguez-García, A. González-Castro, C. Garcia, O. Rubio, Lara Ventura, Alexandra López, M. C. de la Torre, E. Keough, V. Arauzo, C. Hermosa, C. Sánchez, A. Tizón, E. Tenza, C. Laborda, S. Cabañes, V. Lacueva, M. del Mar Fernández, A. Arnau, R. Fernandez   +21 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Deriving ventilation imaging from 4DCT by deep convolutional neural network [PDF]

, 2018
Purpose: Functional imaging is emerging as an important tool for lung cancer treatment planning and evaluation. Compared with traditional methods such as nuclear medicine ventilation-perfusion (VQ), positron emission tomography (PET), single photon emission computer tomography (SPECT), or magnetic resonance imaging (MRI), which use contrast agents to ...
arxiv   +1 more source

An exploration of heat consumption for production of domestic hot water in central heat substations/Šilumos sąnaudų tyrimas karštam vandeniui ruošti centriniuose šilumos punktuose

Journal of Civil Engineering and Management, 1998
Didžioji dalis šilumos vartotojų Vilniaus mieste šilumą gauna iš šilumos tinklų. Plačiausiai taikoma toliau aprašyta šilumos tiekiamoji schema. Iš šilumos šaltinio šiluma tiekiama iki centrinių šilumos punktų (CŠP) dvivamzde sistema.
Edvard Tuomas, Alfonsas K. Skrinska
doaj   +1 more source

Is protocolised weaning that includes early extubation onto non-invasive ventilation more cost effective than protocolised weaning without non-invasive ventilation? Findings from the Breathe Study [PDF]

, 2020
Background Optimising techniques to wean patients from invasive mechanical ventilation (IMV) remains a key goal of intensive care practice. The use of non-invasive ventilation (NIV) as a weaning strategy (transitioning patients who are difficult to wean
Couper, Keith, Dritsaki, Melina, Gates, Simon, HASH(0x5574f3dd5228), Khan, Iftekhar, Lall, Ranjit, Lamb, Sally, Maredza, Mandy, Mistry, Dipesh, Perkins, Gavin D., Petrou, Stavros   +10 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source