Results 41 to 50 of about 3,522,828 (292)
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Flexible bronchoscopy during mechanical ventilation. Why and why not
, 2022 Flexible bronchoscopy has been utilized in the intensive care units and in mechanically ventilated patients for many decades. The procedure is reasonably safe and has wide range of diagnostic and therapeutic benefits in patients undergoing mechanical ...
Kevin Benavente +6 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
BuildingsThe rising demand for building cooling has led to increased energy consumption and environmental concerns. This study aims to examine the effectiveness of natural ventilation strategies as sustainable approaches in arid and semi-arid climates, focusing ...
Ahmad Walid Ayoobi +2 more
doaj +1 more source
Advances in Civil Engineering, 2021 The Bohai Strait Channel (BSC) is a strategic infrastructure project connecting the Shandong Peninsula and northeastern China. One challenge related to building the BSC tunnel portion is that ventilation shafts cannot be constructed due to certain ...
Yimin Wu +7 more
doaj +1 more source
Calculating the work of breathing during mechanical ventilation
, 2021 Left figure: Passive patient esophageal pressure (Pes) in cmH2O on x-axis versus tidal volume in ml on y-axis. Green dashed line represents the chest wall compliance Right figure: same patient actively breathing on pressure support ventilation. (Pes) in
Mia Shokry +3 more
core +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
Improving non-invasive ventilation documentation [PDF]
BMJ Quality Improvement Reports, 2014 Abstract Record keeping for patients on non-invasive ventilation (NIV) at St. Georges Hospital is poor. The initial NIV prescription is often not recorded, and changes to the NIV prescription or the rationale for the changes (ABG results) are also poorly documented.
Smith, Matthew, Elkheir, Natalie
openaire +2 more sources
Four Truths of Mechanical Ventilation and the Ten-Fold Path to Enlightenment
, 2021 : The Four Truths 1. The truth of confusion 2. The truth of the origin of confusion 3. The truth of the cessation of confusion 4. The truth of the path leading to the cessation of confusion The 10-Fold Path 1.
Chatburn, Robert +2 more
core +1 more source
FEBS Open Bio, EarlyView.During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa +4 more
wiley +1 more source