Results 131 to 140 of about 273,929 (243)

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

open access: yesAdvanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao   +12 more
wiley   +1 more source

Ex-PALM: a negative pressure ventilation system for air leak evaluation in <i>ex vivo</i> lungs. [PDF]

open access: yesFront Bioeng Biotechnol
Vartazarmian M   +8 more
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

open access: yesAdvanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun   +13 more
wiley   +1 more source

Thermal stability of multi-tier layer hen housing with all-year sidewall inlet ventilation system. [PDF]

open access: yesPoult Sci
Chen YJ   +8 more
europepmc   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

open access: yesAdvanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi   +4 more
wiley   +1 more source

How to get cheap clean air? Implementation of an affordable high-efficient air filtration ventilation system for operating theatres in a low-resource setting. [PDF]

open access: yesGMS Hyg Infect Control
Doll CL   +8 more
europepmc   +1 more source

Bioinspired Cold‐Laminated Ultrathin Hydrogels as a Broadly Adaptive Platform for Physiological Monitoring

open access: yesAdvanced Science, EarlyView.
A cold‐lamination strategy is introduced to fabricate ultrathin, nanomesh‐reinforced hydrogel bioelectronics with controlled thickness, tunable mechanics, and reversible adhesion. By mechanically interlocking a TPU nanomesh within a temperature‐responsive hydrogel, the platform enables robust epidermal and implantable cardiac interfaces, supporting ...
Hui Chen   +10 more
wiley   +1 more source

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