Results 131 to 140 of about 10,362,161 (244)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Multifaceted Control Interventions for Healthcare-associated Infections in a Kidney Transplant Intensive Care Unit: Clinical Outcome Improvement and Bundle Adherence

Transplantation Direct
Background. Healthcare-associated infections (HAIs) are preventable complications that overwhelm the healthcare system. The implementation of multifaceted control intervention actions in the intensive care setting modifies clinical outcomes, but its ...
Luana Oliveira Calegari, MD, Maria Bethânia Peruzzo, MD, Renato Demarchi Foresto, MD, PhD, Helio Tedesco-Silva, MD, PhD, José Medina Pestana, MD, PhD, Lúcio R. Requião-Moura, MD, PhD   +5 more
doaj   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Real-world analysis of ventilator-associated technical adverse events and preventive maintenance deficiencies under materiovigilance surveillance [PDF]

Jitendra Patidar, Anuja Jha, Mohammad Nadeem Khan, Rashmi Mahajan, Pooja Reddy   +4 more
openalex   +1 more source

Synergistic Effects in Multistate Black Electro‐Thermochromic Smart Windows for Energy‐Efficient Modulation of Solar Heating

Advanced Science, EarlyView.
Hybrid electro‐thermochromic smart windows are developed for dynamic climate control by integrating a redox‐matched black electrochromic gel with a paraffin‐based thermochromic film. This synergistic combination enables multimodal solar modulation, where photothermal heating from the electrochromic layer triggers thermochromic activation at lower ...
Xilu Wu, Lorenzo Vallan, Hao Li, Jaume Ramon Otaegui, Silvia Mena, Weizhong Jiang, Hongzhi Wang, Jonathan C. Barnes, Daniel Ruiz‐Molina, Kerui Li, Jordi Hernando, Claudio Roscini, Gonzalo Guirado   +12 more
wiley   +1 more source

Epidemiological patterns of bacterial and fungal healthcare-associated infection outbreaks in Ministry of Health hospitals in Saudi Arabia, 2020-2021

Journal of Infection and Public Health
Background: Healthcare-Associated Infections (HAI) outbreaks remain a huge challenge to the healthcare sectors worldwide. Their impact on morbidity and mortality, economic and healthcare burden remains a public health problem and a challenge to the HAI ...
Mohammed A. Kilani, Bashaier A. Aljohar, Yazeed A. Alayed, Najim Z. Alshahrani, Hala R. Shiha, Ghada Bin Saleh, Nasser H. Alshanbari, Khalid H. Alanazi   +7 more
doaj   +1 more source

Knowledge, Attitudes, and Practices of Critical Care Nurses Regarding Ventilator-Associated Event Prevention at King Abdulaziz Hospital, Al Ahsa, Saudi Arabia [PDF]

Beverly Ann F. Silva, Prisca Dlamini, Mia Garcia, Jennifer Ann Camero   +3 more
openalex   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Ventilator-Associated Events in Critical Care: Pathophysiology, Surveillance, Prevention, and Management—A Comprehensive Review

Indunil Karunarathna, Asoka Karunarathna
openalex   +2 more sources

Incidence, Characteristics, and Outcomes of Ventilator-associated Events during the COVID-19 Pandemic. [PDF]

Ann Am Thorac Soc, 2022
Weinberger J, Rhee C, Klompas M.
europepmc   +1 more source