Advanced Science, EarlyView.Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai +9 more
wiley +1 more source
DEMAND CONTROLLED VENTILATION AND CLASSROOM VENTILATION
, 2013 This document summarizes a research effort on demand controlled ventilation and classroom ventilation. The research on demand controlled ventilation included field studies and building energy modeling. Major findings included: ? The single-location carbon dioxide sensors widely used for demand controlled ventilation frequently have large errors and ...
openaire +2 more sources
Adaptive and Highly Efficient Thermoregulation Based on Multi‐Dimensional Janus Film
Advanced Science, EarlyView.A switchable TiO2/MXene/PDMS Janus membrane enables dual‐mode radiative cooling and solar heating, achieving sub‐ambient cooling of 17.89°C and above‐ambient heating of 13.82°C. Adaptive temperature regulation was demonstrated with a low power integrated autonomous smart curtain system, providing a sustainable and energy‐efficient alternative for ...
Yuqing Shi +6 more
wiley +1 more source
Home mechanical ventilator device transitions: A narrative review of clinical considerations to create a transition tool. [PDF]
Can J Respir TherCithiravel N +5 more
europepmc +1 more source
Advanced Science, EarlyView.Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen +12 more
wiley +1 more source
Simulating crisis triage: a methodological framework for evaluating ventilator allocation under crisis standards of care. [PDF]
BMC Med Res MethodolWalsh BC +4 more
europepmc +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Improving Ventilator Care Quality Through a Structured Ventilator Pathway: A Retrospective Pre-Post Quality Improvement Study. [PDF]
CureusRathod D +5 more
europepmc +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
Aerosol Delivery With a Vibrating Mesh Nebulizer Across Tidal Volume-Based Pediatric Invasive Ventilation Models: An In Vitro Evaluation. [PDF]
Crit Care ExplorMiura S +4 more
europepmc +1 more source