Results 131 to 140 of about 12,515 (240)

Challenges of Ventilator Procurement and Distribution in the ICU During the COVID-19 Pandemic: A Scoping Review. [PDF]

open access: yesCrit Care Explor
Wang D   +7 more
europepmc   +1 more source

Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis

open access: yesAdvanced Science, EarlyView.
Bone marrow monocytes infiltrate the West Nile virus‐infected brain and differentiate into HIF1‐α⁺ monocyte‐derived cells (MCs) that diverge into protective, antigen‐presenting or inflammatory, iNOS⁺ MCs with distinct metabolic programs and functions.
Claire L. Wishart   +4 more
wiley   +1 more source

Humidity‐Controlled Smart Window with Synchronous Solar and Thermal Radiation Regulation

open access: yesAdvanced Science, EarlyView.
A humidity‐responsive PTFE/PVA composite membrane with a nanoporous structure is developed and integrated between double glazing for the construction of smart windows. By modulating the interlayer humidity levels, this system achieves dynamic solar modulation (54.4%) and thermal radiation modulation (51.4%) via reversible water vapor adsorption ...
Guozheng Li   +5 more
wiley   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li   +5 more
wiley   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

open access: yesAdvanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng   +9 more
wiley   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

open access: yesAdvanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song   +17 more
wiley   +1 more source

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