Results 91 to 100 of about 237,495 (309)

Right Ventricular Dysfunction in Asymptomatic Diabetic Patients [PDF]

Diabetes Care, 2004
Diabetes is thoroughly evidenced to increase the risk of development of heart failure even in the absence of frequently coexisting comorbidities such as coronary artery disease and hypertension. Cardiac adverse effects influenced by diabetes have been demonstrated thus far for the left ventricle, particularly systolic and diastolic dysfunction ...
Kosmala, Wojciech, Colonna, Paolo, Przewlocka-Kosmala, Monika, Mazurek, Walentyna   +3 more
openaire   +3 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Subcostal TAPSE: a retrospective analysis of a novel right ventricle function assessment method from the subcostal position in patients with sepsis

The Ultrasound Journal, 2019
Background Tricuspid annular plane systolic excursion (TAPSE) is frequently used as an objective measure of right-ventricular dysfunction. Abnormal TAPSE values are associated with poor prognosis in a number of disease states; however, the measure is not
Alison B. Main, Rachel Braham, Daniel Campbell, Andrew J. Inglis, Anthony McLean, Sam Orde   +5 more
doaj   +1 more source

Sudden cardiac death in patients with ischemic heart failure undergoing coronary artery bypass grafting results from the STICH randomized clinical trial (Surgical Treatment for Ischemic Heart Failure) [PDF]

, 2017
Background—The risk of sudden cardiac death (SCD) in patients with heart failure following CABG has not been examined in a contemporary clinical trial of surgical revascularization. This analysis describes the incidence, timing and clinical predictors of
Al-Khatib, Sana M., Carson, Peter E., Cleland, John G.F., Desvigne-Nickens, Patrice M., Feldman, Arthur M., Lang, Irene M., Lee, Kerry L., Nicolau, Jose C., Pokorney, Sean, Rao, Meena P., Romanov, Alexander, Rouleau, Jean L., Selzman, Craig H., She, Lilin, Siepe, Matthias, Stepinska, Janina, Sueta, Carla, Tungsubutra, Wiwun, Velazquez, Eric J., Yii, Michael   +19 more
core   +2 more sources

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Arrhythmogenic right ventricular cardiomyopathy in monozygotic twin sisters, and persistent left superior vena cava in one complicating implantation of ICD

Türk Kardiyoloji Derneği Arşivi, 2015
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiomyopathy characterized histologically by fibro-fatty replacement of heart muscle, and clinically by ventricular arrhythmias and right ventricular dysfunction.
Mehmet Ali Astarcıoğlu, Mehmet Yaymacı, Taner Şen, Celal Kilit, Basri Amasyalı   +4 more
doaj   +1 more source

Presyncope Is Associated with Intensive Care Unit Admission in Emergency Department Patients with Acute Pulmonary Embolism [PDF]

, 2020
Introduction: Syncope is common among emergency department (ED) patients with acute pulmonary embolism (PE) and indicates a higher acuity and worse prognosis than in patients without syncope.
Abraham, Ashley S., Bahl, Disha, Clague, Victoria A., Cotton, Dale M., Engelhart, Darcy C., Huang, Jie, Krauss, William C., Mark, Dustin G., Othieno, Alisha A., Reed, Mary E., Swanson, William P., Vinson, David R.   +11 more
core  

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Tricuspid Annular Plane of Systolic Excursion for the Evaluation of Patients with Severe Sepsis and Septic Shock [PDF]

, 2020
Introduction: Sepsis is a systemic infection that can rapidly progress into multi organ failure and shock if left untreated. Previous studies have demonstrated the utility of point of care ultrasound (POCUS) in the evaluation of patients with sepsis ...
Ali, Qumber, Fischetti, Chanel, Fox, John C., Lahham, Shadi, Lee, Clifton, Moeller, John, Saadat, Soheil, Thompson, Maxwell   +7 more
core