Results 31 to 40 of about 142,198 (255)

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Racing hearts in the ED: When atrial tachyarrhythmias Herald hidden culprits

JEM Reports
Background: Atrial Fibrillation (AF) is the most common sustained arrhythmia in the general population. Patients with atrial fibrillations commonly go to Emergency Departments (ED) with complications or aggravation of symptoms.
Anas Mohammed Muthanikkatt, Bukya Venkat Yogesh Naik, Muhsina Manayath Kunjumohammed, Anandhi Devendiran, Somasundaram Anukarthika, Senthamizhan Sundaramoorthy   +5 more
doaj   +1 more source

Discordant Alternans as a Mechanism for Initiation of Ventricular Fibrillation In Vitro

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Ventricular tachyarrhythmias are often preceded by short sequences of premature ventricular complexes. In a previous study, a restitution‐based computational model predicted which sequences of stimulated premature complexes were most likely to
Laura M. Muñoz, Anna R. M. Gelzer, Flavio H. Fenton, Wei Qian, WeiYe Lin, Robert F. Gilmour, Niels F. Otani   +6 more
doaj   +1 more source

Pulseless Electrical Activity as the Initial Cardiac Arrest Rhythm: Importance of Preexisting Left Ventricular Function

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Pulseless electrical activity (PEA) is a common initial rhythm in cardiac arrest. A substantial number of PEA arrests are caused by coronary ischemia in the setting of acute coronary occlusion, but the underlying mechanism is not well ...
Daniel I. Ambinder, Kaustubha D. Patil, Hikmet Kadioglu, Pace S. Wetstein, Richard S. Tunin, Sarah J. Fink, Susumu Tao, Giulio Agnetti, Henry R. Halperin   +8 more
doaj   +1 more source

Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring

Advanced Science, EarlyView.
This study presents a semantic representation framework for clinically interpretable cardiac monitoring from contactless radio signals. It formulates radio semantic learning as an information‐bottleneck problem and approximates the objective via intra‐modal compression and cross‐modal alignment, structuring radio measurements into meaningful semantic ...
Jinbo Chen, Haoyu Wang, Guixin Xu, Yuqin Yuan, Xinmeng Cai, Zhengwu Wei, Dongheng Zhang, Qibin Sun, Tianwei Zhang, Cuntai Guan, Yan Chen   +10 more
wiley   +1 more source

Novel SCN5A mutation associated with idiopathic ventricular fibrillation due to subclinical Brugada syndrome

Cardiogenetics, 2011
Idiopathic ventricular fibrillation can be caused by subclinical channelopathies such as Brugada syndrome. Our objective is to study the clinical behaviour of a new SCN5A mutation found in a woman with idiopathic ventricular fibrillation.
Juan Jiménez-Jáimez, Miguel Álvarez-López, Luis Tercedor-Sánchez, Pablo Santiago, Maria Algarra, Rocio Peñas, Francisca Valverde, Rafael Melgares-Moreno   +7 more
doaj   +1 more source

Management of sudden cardiac death in cardiac sarcoidosis using the wearable cardioverter defibrillator. [PDF]

PLoS ONE, 2018
Patients with cardiac sarcoidosis are at increased risk of ventricular tachycardia/fibrillation.We tested the hypothesis that the wearable cardioverter defibrillator can be used to mitigate the risk of sudden cardiac death among cardiac sarcoidosis ...
Dirk Skowasch, Steven Ringquist, Georg Nickenig, René Andrié   +3 more
doaj   +1 more source

AI‐Assisted IoT‐Enabled ECG Monitoring: Integrating Foundational and Generative AI Tools for Sustainable Smart Healthcare—Recent Trends

AI &Innovation, EarlyView.
ABSTRACT The rapid evolution of the Internet of Things (IoT) has significantly advanced the field of electrocardiogram (ECG) monitoring, enabling real‐time, remote, and patient‐centric cardiac care. This paper presents a comprehensive survey of AI assisted IoT‐based ECG monitoring systems, focusing on the integration of emerging technologies such as ...
Amrita Choudhury, Kandarpa Kumar Sarma, Lachit Dutta   +2 more
wiley   +1 more source