Results 41 to 50 of about 570,572 (255)
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Intensive Exercise Training Improves Cardiac Electrical Stability in Myocardial‐Infarcted Rats
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundModerate exercise training has been shown to decrease sudden cardiac death post myocardial infarction. However, the effects of intensive exercise are still controversial.
Horesh Dor‐Haim +3 more
doaj +1 more source
Advanced Science, EarlyView.Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler +4 more
wiley +1 more source
Cardiac Device Algorithms for Optimal Outcomes in Patients with Sick Sinus Syndrome [PDF]
, 2013 Sick sinus syndrome (SSS) is a relatively common chronic condition affecting the electrical conduction system of the heart. In the absence of any reversible cause of SSS, the most effective treatment is implantation of a permanent pacemaker to maintain ...
CURRY, JANE,KATHERINE
core
Role of cardiac resynchronization therapy in the development of new-onset atrial fibrillation: A single-center prospective study. [PDF]
, 2012 Albeit several studies examined the association between cardiac resynchronization therapy (CRT) and atrial fibrillation (AF) in heart failure (HF), results are still unclear and quite conflicting.
Salvatore d'Ascia +5 more
core +1 more source
Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning
Advanced Science, EarlyView.Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin +13 more
wiley +1 more source
Racing hearts in the ED: When atrial tachyarrhythmias Herald hidden culprits
JEM ReportsBackground: Atrial Fibrillation (AF) is the most common sustained arrhythmia in the general population. Patients with atrial fibrillations commonly go to Emergency Departments (ED) with complications or aggravation of symptoms.
Anas Mohammed Muthanikkatt +5 more
doaj +1 more source
Atrial fibrillation mimicking ventricular fibrillation confuses an automated external defibrillator
, 2018 Atrial fibrillation mimicking ventricular fibrillation confuses an automated external ...
Blom, M. T. +9 more
core +1 more source
Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley +1 more source
Cardiogenetics, 2011 Idiopathic ventricular fibrillation can be caused by subclinical channelopathies such as Brugada syndrome. Our objective is to study the clinical behaviour of a new SCN5A mutation found in a woman with idiopathic ventricular fibrillation.
Juan Jiménez-Jáimez +7 more
doaj +1 more source