Results 281 to 290 of about 188,365 (337)

Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling. [PDF]

Front Cardiovasc Med
Cai H, Yu C, Li X, Wang X, Yang Y, Lan C.   +5 more
europepmc   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, EarlyView.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction. [PDF]

Acta Pharm Sin B
Yao H, He Q, Wei S, Xiang L, Luo Y, Huang C, Liu W, Zheng C, Li X, Gao Y.   +9 more
europepmc   +1 more source

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Interdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li   +12 more
wiley   +1 more source

Nanoparticle‐integrated electrostimulation‐responsive biomaterials: Innovations in drug delivery and tissue repair in clinical regenerative medicine

Interdisciplinary Medicine, EarlyView.
Schematic representation of nanoparticle‐integrated electrostimulation‐responsive biomaterials for controlled drug delivery and tissue regeneration. Electroactive scaffolds including conductive polymers, electroresponsive hydrogels, and piezoelectric matrices are shown incorporating therapeutic nanoparticles (such as iron oxide, silver, and carbon ...
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

Phosphorylation of CRYAB induces a condensatopathy to worsen post-myocardial infarction left ventricular remodeling. [PDF]

J Clin Invest
Islam M, Rawnsley DR, Ma X, Navid W, Zhao C, Guan X, Foroughi L, Murphy JT, Navid H, Weinheimer CJ, Kovacs A, Nigro J, Diwan A, Chang RP, Kumari M, Young ME, Razani B, Margulies KB, Abdellatif M, Sedej S, Javaheri A, Covey DF, Mani K, Diwan A.   +23 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Regulatory T cells: a promising new therapeutic target in ventricular remodeling after myocardial infarction. [PDF]

Front Immunol
Qin Y, Li M, Liu H.
europepmc   +1 more source

A Label‐Free Hyperspectral Imaging Device for Ex Vivo Characterization and Grading of Meningioma Tissues

Journal of Biophotonics, EarlyView.
HyperProbe1.1 enables rapid, label‐free biochemical mapping of freshly resected meningiomas. By quantifying endogenous biomarkers such as cytochrome c oxidase, hemoglobin derivatives, and lipids, the system reveals molecular signatures consistent with tumor grading and generates spatial maps that visualize metabolic and vascular heterogeneity across ...
Pietro Ricci, Camilla Bonaudo, Ivan Ezhov, Anam Toaha, Dorotea Nardini, Manuel Camelia, Federica Lucidi, Filippo Nozzoli, Tim Mach, Ilias Tachtsidis, Daniel Rueckert, Alessandro Della Puppa, Luca Giannoni, Francesco S. Pavone   +13 more
wiley   +1 more source