Results 261 to 270 of about 123,523 (307)

MicroRNAs in right ventricular remodelling

Cardiovascular Research, 2017
Right ventricular (RV) remodelling is a lesser understood process of the chronic, progressive transformation of the RV structure leading to reduced functional capacity and subsequent failure. Besides conditions concerning whole hearts, some pathology selectively affects the RV, leading to a distinct RV-specific clinical phenotype.
Sandor, Batkai, Christian, Bär, Thomas, Thum   +2 more
openaire   +2 more sources

Prevention of ventricular remodeling

Journal of Laboratory and Clinical Medicine, 1998
Abstract Despite the major advances in our understanding of the process of ventricular remodeling, many issues remain unresolved. Some relate to the ongoing question of which signals are important in initiating structural changes in the myocardium. Specifically, a better understanding of infarct zone healing may allow for reduced regional and global ...
openaire   +2 more sources

Myocyte proliferation and ventricular remodeling

Journal of Cardiac Failure, 2002
Improvement in the methodological approach to the analysis of the myocardium has provided clear evidence of cardiac myocyte proliferation, questioning the general belief that the growth of the adult heart under physiological and pathological conditions can occur only by cellular hypertrophy.
Annarosa, Leri, Jan, Kajstura, Piero, Anversa   +2 more
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Aldosterone and Left Ventricular Remodeling

Hormone and Metabolic Research, 2015
AbstractExperimental and clinical evidence obtained in the last 2 decades clearly indicates that protracted exposure to inappropriately elevated aldosterone levels causes significant changes in left ventricular structure and function. Animal studies have demonstrated that aldosterone induces myocardial inflammatory changes and fibrosis in the presence ...
CATENA, Cristiana, COLUSSI, Gian Luca, Brosolo, Gabriele, Novello, Marileda, SECHI, Leonardo Alberto   +4 more
openaire   +4 more sources

Myocyte renewal and ventricular remodelling

Nature, 2002
Remaining young at heart is a desirable but elusive goal. Unbeknown to us, however, myocyte regeneration may accomplish just that. Continuous cell renewal in the adult myocardium was thought to be impossible, but multipotent cardiac stem cells may be able to renew the myocardium and, under certain circumstances, can be coaxed to repair the broken heart
Piero, Anversa, Bernardo, Nadal-Ginard
openaire   +2 more sources

Ventricular remodeling in heart failure

Journal of Cardiac Failure, 2002
This review briefly highlights the major mechanisms of left ventricular (LV) remodeling following myocardial infarction in heart failure and presents novel strategies to limit infarct size and retard the progression of LV remodeling. This is important since interventions that have been shown to improve mortality in patients with heart failure such as ...
Mohamed A, Gaballa, Steven, Goldman
openaire   +2 more sources

Pathophysiological Basis of Right Ventricular Remodeling

Journal of Cardiovascular Pharmacology and Therapeutics, 2007
The pathophysiology of right ventricular (RV) remodeling is a complex process and may include unique elements not observed in left ventricular (LV) remodeling. The RV also has a relatively irregular geometry not accounted for in LV analyses. RV remodeling includes basic changes in geometry, wall thickness, and ventricular pressure-volume relationships.
Marcus, Kret, Rohit, Arora
exaly   +3 more sources

Ventricular remodelling: consequences and therapy

European Heart Journal, 1993
The mammalian left ventricle can change its size and shape in response to a variety of stimuli including loss of tissue and external work. These changes in size and shape, defined as remodelling, are the sum total of a number of processes that involve the myocyte and the interstitial fibrous structures which provide the matrix in which the myocyte ...
H N, Sabbah, S, Goldstein
openaire   +2 more sources

Role of apoptosis in ventricular remodeling

Current Heart Failure Reports, 2005
Cell loss is a common feature in the failing heart, and this contributes to the relentless progression seen in patients with heart failure. Apoptosis is one of the most common causes of cell loss in animals and humans with heart failure. There is increasing evidence that apoptosis, even while occurring in a low-grade manner, can mediate heart failure ...
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Remodeling of ventricular repolarization in experimental right ventricular hypertrophy

Journal of Electrocardiology, 2017
To understand electrophysiological mechanisms that underlie the progression of compensated right ventricular hypertrophy (RVH) to heart failure, the purpose of the study was to evaluate remodeling of ventricular repolarization in connection with hemodynamic abnormalities and vulnerability of the heart ventricles to arrhythmias in RVH rats with ...
S N, Kharin, V V, Krandycheva, A S, Tsvetkova, K V, Shumikhin   +3 more
openaire   +2 more sources