Results 81 to 90 of about 188,365 (337)
Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]
, 2013 Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin +7 more
core +1 more source
NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction
Advanced Science, EarlyView.NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu +15 more
wiley +1 more source
Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]
, 2016 BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C +12 more
core +1 more source
Advanced Science, EarlyView.Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti +11 more
wiley +1 more source
Echocardiographic phenotyping of the continuum of myocardial functional remodelling in left ventricular hypertrophy - machine learning validated with cardiac magnetic resonance [PDF]
, 2021 Filip Lončarić +6 more
openalex +1 more source
Advanced Science, EarlyView.RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng +6 more
wiley +1 more source
Ventricular‐Arterial Function and Coupling in the Adult Fontan Circulation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 Background In adult Fontan patients, ventricular or arterial dysfunction may impact homeostasis of the Fontan circulation and predispose to heart failure. We sought to characterize ventricular‐arterial (VA) properties in adult Fontan patients.
Hirofumi Saiki +4 more
doaj +1 more source
Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction
Advanced Science, EarlyView.This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma +11 more
wiley +1 more source
An unusual case of cardiac dysfunction after left ventricular reconstruction
Journal of Cardiothoracic Surgery, 2006 This report describes an unusual cause of low cardiac output after coronary artery bypass grafting and left ventricular remodeling. It details left ventricular remodeling techniques and discusses the most recent advances and outcomes.
Fedoruk Lynn M, Kron Irving L
doaj +1 more source
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source