Results 81 to 90 of about 1,071,989 (385)

Inflammatory Mediators Drive Adverse Right Ventricular Remodeling and Dysfunction and Serve as Potential Biomarkers

Frontiers in Physiology, 2018
Adverse right ventricular (RV) remodeling leads to ventricular dysfunction and failure that represents an important determinant of outcome in patients with pulmonary hypertension (PH). Recent evidence indicates that inflammatory activation contributes to
A. Sydykov, A. Mamazhakypov, A. Petrović, D. Kosanovic, A. Sarybaev, N. Weissmann, H. Ghofrani, R. Schermuly   +7 more
semanticscholar   +1 more source

Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension [PDF]

, 2017
Objective: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesise that in PASMCs, serotonin induces
Harvey, Adam P., Hood, Katie Y., MacLean, Margaret R., Mair, Kirsty M., Montezano, Augusto C., Touyz, Rhian M.   +5 more
core   +2 more sources

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad‐Ali Shahbazi, Hélder A. Santos   +6 more
wiley   +1 more source

Right Atrial-to-Right Ventricular Area

JACC: Advances
Background: Severe secondary tricuspid regurgitation (STR) in heart failure patients is associated with excess mortality. Quantification associated risk assessment, remains challenging, specifically with contextual anatomic variability.
Charlotte Jantsch, MD, Sophia Koschatko, MD, TingTing Wu, MD, Christoph Torrefranca, MD, Kseniya Halavina, MD, Varius Dannenberg, MD, Caglayan Demirel, MD, Christian Nitsche, MD, PhD, Laurenz Hauptmann, MD, Maximilian Autherith, MD, Georg Goliasch, MD, PhD, Christian Hengstenberg, MD, Noemi Pavo, MD, PhD, Philipp E. Bartko, MD, PhD, Gregor Heitzinger, MD, PhD   +14 more
doaj   +1 more source

Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 1D simulation study. [PDF]

PLoS ONE, 2014
Heart failure is a final common pathway or descriptor for various cardiac pathologies. It is associated with sudden cardiac death, which is frequently caused by ventricular arrhythmias.
Juan F Gomez, Karen Cardona, Lucia Romero, Jose M Ferrero, Beatriz Trenor   +4 more
doaj   +1 more source

Defining left ventricular remodeling following acute ST-segment elevation myocardial infarction using cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance, 2017
BackgroundThe assessment of post-myocardial infarction (MI) left ventricular (LV) remodeling by cardiovascular magnetic resonance (CMR) currently uses criteria defined by echocardiography.
H. Bulluck, Y. Go, G. Crimi, A. Ludman, S. Rosmini, A. Abdel‐Gadir, A. Bhuva, T. Treibel, M. Fontana, S. Pica, C. Raineri, A. Sirker, A. Herrey, C. Manisty, A. Groves, J. Moon, D. Hausenloy   +16 more
semanticscholar   +1 more source

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. [PDF]

, 2013
Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a central role in pathological cardiac hypertrophy, but the mechanisms by which it modulates gene activity in the nucleus to mediate hypertrophic signaling remain unclear. Here, we report that
An, Woojin, Awad, Salma, Bai, Yan, Bers, Donald, Kedes, Larry, Kunhi, Muhammad, Little, Gillian H, Poizat, Coralie   +7 more
core   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. [PDF]

, 2002
BackgroundIron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger ...
Chew, Herbert George, Gibbs, Brett Jason, Hearthway, Megan Lesley, Motsko, Madelyne, Mullendore, Michael Eugene, Premo, Daniel Aaron, Sappington, Andrea, Turner, Lexa Rae, Walker, LeeAnn   +8 more
core   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source