Results 21 to 30 of about 29,656 (290)

Vectorcardiographic Ventricular Gradient with Constituents, and Myocardial Action Potential Parameter Distribution

open access: yesMeasurement Science Review, 2022
Theoretical grounds of integral vectors of ventricular depolarization and repolarization and their sum, i.e., the spatial ventricular gradient, have been studied.
Aidu Eduard A. I., Trunov Vladimir G.
doaj   +1 more source

A protocol combining current- and voltage-clamp provides a novel and useful three-dimensional representation of cardiac action potential

open access: yesJournal of Biological Research, 2014
A compact three-dimensional representation of cardiac action potential (AP) properties in terms of current source is presented here. The experimental protocol used to obtain such representation is based on the measure of instantaneous current-voltage ...
Massimiliano Zaniboni   +1 more
doaj   +1 more source

Calcium-activated potassium current modulates ventricular repolarization in chronic heart failure.

open access: yesPLoS ONE, 2014
The role of I(KCa) in cardiac repolarization remains controversial and varies across species. The relevance of the current as a therapeutic target is therefore undefined. We examined the cellular electrophysiologic effects of I(KCa) blockade in controls,
Ingrid M Bonilla   +14 more
doaj   +1 more source

Beat-to-beat variability of ventricular repolarization reveals sex-specific instability and proarrhythmic risk. [PDF]

open access: yesJ Physiol
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Sato D, Santini L, Coppini R, Grandi E.
europepmc   +2 more sources

Impact of hypokalemia on electromechanical window, excitation wavelength and repolarization gradients in guinea-pig and rabbit hearts. [PDF]

open access: yesPLoS ONE, 2014
Normal hearts exhibit a positive time difference between the end of ventricular contraction and the end of QT interval, which is referred to as the electromechanical (EM) window.
Oleg E Osadchii
doaj   +1 more source

Diabetes mellitus attenuates the repolarization reserve in mammalian heart

open access: yes, 2007
Objective: In diabetes mellitus several cardiac electrophysiological parameters are known to be affected. In rodent experimental diabetes models changes in these parameters were reported, but no such data are available in other mammalian species ...
Lengyel, Csaba Attila   +12 more
core   +1 more source

Dispersion of ventricular repolarization and refractory period [PDF]

open access: yesCardiovascular Research, 2001
Time for primary review 34 days. In their classic studies published in 1964, Han, Moe and co-workers [1,2] established an association between nonuniform recovery of excitability and lowered fibrillation threshold. They concluded that “those agencies known to favour the development of ventricular fibrillation were found to increase the temporal ...
F L, Burton, S M, Cobbe
openaire   +2 more sources

Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp

open access: yesFrontiers in Pharmacology, 2022
The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death.
Chunyun Du   +9 more
doaj   +1 more source

RISK STRATIFICATION OF SUDDEN CARDIAC DEATH IN EARLY REPOLARIZATION SYNDROME

open access: yesŽurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019
The article describes approaches to risk stratification of sudden cardiac death in early ventricular repolarization syndrome, as one of the variants of J-wave syndrome, on the basis of clinical, anamnestic and electrocardiographic criteria.
Shpak N. V.   +3 more
doaj   +1 more source

Chamber‐Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function

open access: yesAdvanced Healthcare Materials, EarlyView.
Chamber‐specific decellularized extracellular matrices (ECMs) were developed, preserving native proteomic profiles of ventricular and atrial myocardium. These innate biochemical cues differentially modulate cardiomyocyte subtypes to drive engineered heart tissue development and function, highlighting the importance of incorporating regional ECM cues in
Dong Gyu Hwang   +7 more
wiley   +1 more source

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