Results 41 to 50 of about 391,145 (293)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Congenital Aneurysmal Tunnel of the Trabecular Muscular Interventricular Septum or a Partially Closed Ventricular Septal Defect? A Case Report with Review of Literature

Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging
Isolated congenital aneurysm-like deformity of the muscular interventricular septum is rare and may be associated with other congenital heart defects, ventricular dysfunction, conduction disturbances, and chromosomal abnormalities. It may be a partial or
Madhu Shukla, Jagdish Chander Mohan
doaj   +1 more source

Double orifice mitral valve associated with Ventricular Septal Defect in an infant : case report [PDF]

, 2011
Double orifice mitral valve (DOMV) is an uncommon anomaly characterized by a mitral valve with a single fibrous annulus with two orifices opening into the left ventricle.
Taksande, Amar M., Thomas, E., Goutami, V.   +2 more
core  

Pulmonary atresia with intact ventricular septum: Strategy based on right ventricular morphology [PDF]

, 2003
ObjectivesManagement strategy for pulmonary atresia with intact ventricular septum is controversial. We treated patients with this anomaly according to a management protocol based on our quantitative assessment of right ventricular morphology (index of ...
Murakami, Hirohisa, Oshima, Yoshihiro, Yamaguchi, Masahiro, Yoshida, Masahiro, Yoshimura, Naoki, Ohashi, Hidetaka, Oka, Shigeteru, Tei, Teruo   +7 more
core   +1 more source

Designing Tissue Function Through Embedded Bioprinting Architectures

Advanced Science, EarlyView.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li, Yifei Cao, Jiaxin Lin, Huayong Yang, Hongzhao Zhou   +4 more
wiley   +1 more source

Deteriorated biomechanical properties of human hypertrophied septum in response to cardiomyocyte enlargement, overexpressed collagen, and disarrayed microstructures

Frontiers in Bioengineering and Biotechnology
Hypertrophic cardiomyopathy (HCM) is often caused by genetic mutations, resulting in abnormal thickening of ventricular muscle, particularly the septum, and causing left ventricular outflow tract (LVOT) obstruction and inferior cardiac performance.
Katherine M. Copeland, Houjia Chen, Uday Chintapula, Milad Almasian, Duc Khang Chung, Alan M. Taylor, Yichen Ding, Gaurav Sharma, Michael E. Jessen, Yi Hong, Kytai T. Nguyen, Matthias Peltz, Pietro Bajona, Jun Liao   +13 more
doaj   +1 more source

Ruptura del septum ventricular como complicación de un evento coronario agudo

Revista Colombiana de Cardiología, 2017
La ruptura del septum ventricular (RSV) es una complicación mecánica infrecuente del infarto agudo de miocardio (IAM). Los principales factores de riesgo descritos son la edad avanzada, el género femenino, un primer episodio de IAM y la presencia de ...
William J. Morales-Camacho, José M. Chilatra-Fonseca, Jessica E. Plata-Ortiz, Yisela P. Gómez-Mancilla, Andrea N. Villabona-Suárez, Sergio A. Villabona-Rosales   +5 more
doaj   +1 more source

Ventricular septal defect associated with aneurysm of the membranous septum [PDF]

, 1985
The most common variety of ventricular septal defect, a perimembranous defect, is frequently associated with a so-called aneurysm of the membranous septum. Previous studies have suggested that ventricular septal defects associated with an aneurysm of the
Fricker, Frederick J., Lenox, Cora C., Fischer, Donald R., Park, Sang C., Neches, William H., Mathews, Robert A., Beerman, Lee B., Zuberbuhler, James R.   +7 more
core   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Paced QRS duration predicts left ventricular function in patients with permanent pacemakers – One-year follow-up study using equilibrium radionuclide angiography (ERNA)

Indian Pacing and Electrophysiology Journal, 2015
Permanent pacing, being non physiological, often results in ventricular dysfunction over time. Narrower paced QRS duration from pacing the right ventricular outflow tract septum, might result in relatively preserved ventricular function over long term ...
Gautam Sharma, Sudhir Suryakant Shetkar, Chetan D. Patel, Harmandeep Singh, Nitish Naik, Ambuj Roy, Rajnish Juneja, Prashanthan Sanders   +7 more
doaj   +1 more source