Results 51 to 60 of about 74,924 (301)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Paced QRS duration predicts left ventricular function in patients with permanent pacemakers – One-year follow-up study using equilibrium radionuclide angiography (ERNA)

Indian Pacing and Electrophysiology Journal, 2015
Permanent pacing, being non physiological, often results in ventricular dysfunction over time. Narrower paced QRS duration from pacing the right ventricular outflow tract septum, might result in relatively preserved ventricular function over long term ...
Gautam Sharma, Sudhir Suryakant Shetkar, Chetan D. Patel, Harmandeep Singh, Nitish Naik, Ambuj Roy, Rajnish Juneja, Prashanthan Sanders   +7 more
doaj   +1 more source

Spontaneous resolution of atrial and ventricular septal defects in Malta [PDF]

, 1998
Congenital heart disease (CHD) is the commonest congenital malformation, and ventricular septal defect (VSD) and atrial septal defect (ASD) are the commonest forms of CHD.
Bailey, Mark, Mercieca, Victor, Grech, Victor E.   +2 more
core  

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Deteriorated biomechanical properties of human hypertrophied septum in response to cardiomyocyte enlargement, overexpressed collagen, and disarrayed microstructures

Frontiers in Bioengineering and Biotechnology
Hypertrophic cardiomyopathy (HCM) is often caused by genetic mutations, resulting in abnormal thickening of ventricular muscle, particularly the septum, and causing left ventricular outflow tract (LVOT) obstruction and inferior cardiac performance.
Katherine M. Copeland, Houjia Chen, Uday Chintapula, Milad Almasian, Duc Khang Chung, Alan M. Taylor, Yichen Ding, Gaurav Sharma, Michael E. Jessen, Yi Hong, Kytai T. Nguyen, Matthias Peltz, Pietro Bajona, Jun Liao   +13 more
doaj   +1 more source

The Fate of the Outflow Tract Septal Complex in Relation to the Classification of Ventricular Septal Defects

Journal of Cardiovascular Development and Disease, 2019
It is now established that the entity often described as an “aortopulmonary septal complex„ is better considered as an “outflow tract septal complex„.
Robert H. Anderson, Justin T. Tretter, Diane E. Spicer, Shumpei Mori   +3 more
doaj   +1 more source

One and a half ventricle repair: clinical and animal study [PDF]

, 2013
SUMMARY Since the first description of the so called “one and a half ventricle repair”, published by Billingsly et al. in 1989 1, this type of correction has been applied to several complex congenital cardiac anomalies.
Bhattarai, Anil
core  

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Atrial septal defect--echocardiographic assessment before and after surgical repair.

Acta Médica Portuguesa, 1979
Twenty-two patients with atrial septal defect (ostium secundum type and sinus venosus) were studied by echocardiography before and after surgery. The sizes of the various heart chambers - right and left ventricles, left atrium and aortic root - and the ...
Luís Castro Guimarães, Raquel Andrade Gouveia, Roando Álvares   +2 more
doaj   +1 more source

RCC prolapse causing Aortic regurgitation in a restrictive VSD [PDF]

, 2015
The incidence of aortic right coronary cusp (RCC) prolapse in outlet ventricular septal defect (VSD) is reported at 5%- 16%. Detection of RCC prolapse is critical in patients with outlet VSD because this complication may cause permanent aortic ...
Rabbani, Zeinab, Abqari, Shaad, Meshram, H. S., Gupta, A.   +3 more
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