Results 181 to 190 of about 323,480 (336)

GPR88 localization to primary cilia in neurons is cell-type specific. [PDF]

open access: yesLife Sci Alliance
Li Guan YH   +3 more
europepmc   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings   +6 more
wiley   +1 more source

miR-219a-Robo1 axis acts as a conserved switch for slit-mediated commissural axon guidance. [PDF]

open access: yesiScience
Khot B   +5 more
europepmc   +1 more source

Building Connections to Teach the Nature of Science: An Experienced Science Teacher's Formative Assessment Practices in a High School Classroom

open access: yesJournal of Research in Science Teaching, Volume 63, Issue 2, Page 161-185, February 2026.
ABSTRACT While understanding the nature of science (NOS) is recognized as a key component of science education because of its potential benefits in nurturing scientific literacy, there is currently limited knowledge on how NOS learning can be supported by teachers' ongoing, in‐the‐moment assessment in the classroom.
Wonyong Park   +2 more
wiley   +1 more source

Endosomal microautophagy is activated by specific cellular stresses in trout hepatocytes. [PDF]

open access: yesSci Rep
Vélez EJ   +7 more
europepmc   +1 more source

Disruption of ATP Synthase Spatiotemporal Organization, Ca2+ Dynamics, and Contractile Function in Senescent Cardiomyocytes

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Enhanced ATP hydrolysis, ΔΨm flickering, and destabilized ATP synthase dimers collectively reduce ATP availability in senescent cardiomyocytes. This energy deficit is associated with disrupted Ca2⁺ dynamics and contractility. ABSTRACT Heart disease is the leading cause of death in the elderly population.
Silke Morris   +9 more
wiley   +1 more source

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