Results 211 to 220 of about 281,101 (262)
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
V. Comparisons of the Planet Venus in Right Ascension and N. P. D. with the Star A. S. C. 423, made with the Equatoreal Instrument of the Observatory at Ashurst, on April 9, 1841 [PDF]
R. Snow
openalex +1 more source
Differential G protein activation by the long and short isoforms of the dopamine D2 receptor
British Journal of Pharmacology, Volume 182, Issue 14, Page 3336-3352, July 2025.Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link +4 more
wiley +1 more source
On Observations of Contacts of the Limb of Venus, or Mercury, with that of the Sun [PDF]
, 1877 S. Newcomb
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ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Ueber die nahe Zusammenkunft der drei Planeten Merkur, Venus und Mars am 7. und 8. Febr. 1855. [PDF]
J. Ph. Wolfers
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Allosterism in the adenosine A2A and cannabinoid CB2 heteromer
British Journal of Pharmacology, Volume 182, Issue 14, Page 3371-3384, July 2025.Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent +7 more
wiley +1 more source