Results 181 to 190 of about 69,343 (260)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Predicting Substance Use in Young Adults: The Role of Childhood Adversity. [PDF]

Medicina (Kaunas)
Sinkevicius LV, Sakalauskaite S, Poskus MS, Serapinas D.   +3 more
europepmc   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Prevalence and Characteristics of Workplace Violence Towards Healthcare Workers in Primary Healthcare Settings in Muscat, Oman. [PDF]

Sultan Qaboos Univ Med J
Al Zeedi MASA, Al Maamari BH, AlGhammari KS, Al Mufarrji AR, Al Hasni NS, Al Shuhaimi RY.   +5 more
europepmc   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Relationships between professional value and workplace violence among healthcare workers: an empiricle study from China. [PDF]

Front Med (Lausanne)
Luo H, Li S, Chen Y, Tang X, Tang H, Wang Z.   +5 more
europepmc   +1 more source

Embodied practice in a disembodied time: How the COVID‐19 pandemic shaped direct work with children and young people

Child &Family Social Work, EarlyView.
Abstract The COVID‐19 pandemic and related restrictions imposed in the UK had a significant impact on social work practice with children and young people. As has been widely reported, practitioners were deprived of multisensory information in their assessments and of opportunities to connect with children.
Heather Ellis, Ariane Critchley
wiley   +1 more source

A scoping review of risk determinants for workplace violence in emergency departments. [PDF]

Eur J Emerg Med
Li L, Ouyang L, Lin Y, Wang L, Wu M, Liu D.   +5 more
europepmc   +1 more source

Social and Emotional Functions of Institutional Touch in the Relational Care of Young Children

Child &Family Social Work, EarlyView.
ABSTRACT This study reports results concerning close embodied practices, involving touch, in early childhood care settings in Sweden during the COVID‐19 pandemic. The data—video recordings of everyday practices in contexts of childcare—were collected during various phases of the pandemic. The study demonstrates a broad range of uses of touch, by adults
Asta Cekaite, Madeleine Wirzén
wiley   +1 more source

Experiencing Violence from Animal Owners in Veterinary Medicine: Results of a Nationwide Survey. [PDF]

Healthcare (Basel)
Böckelmann I, Thielmann B.
europepmc   +1 more source