Results 201 to 210 of about 20,882 (259)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Scalable privacy-preserving data analytics for IoMT via FHE and zk-SNARK-enabled edge aggregation. [PDF]

Sci Rep
Ben Othman S, Mihret N.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Data-derived Identity Verification as a principle for the dissemination, harmonization, and artificial intelligence reuse of sensitive biomedical data. [PDF]

JAMIA Open
Cordier BA, Benton ES, Dysinger EJ, McWeeney SK, AI-READI Consortium .   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Correction: Appearance-related attentional bias is associated with dysmorphic appearance concern in individuals with jaw deformity: an eye-tracking study. [PDF]

Front Psychiatry
Matsuzawa K, Honma M, Haga S, Ogura S, Masaoka Y, Izumizaki M, Nakano H.   +6 more
europepmc   +1 more source

A robust and verifiable federated learning framework for preventing data poisonous threats in e-health. [PDF]

Front Public Health
Alruwaili E, Moulahi T.
europepmc   +1 more source

IntegriLAB: a blockchain-enabled electronic lab notebook for reproducible neuroimaging research. [PDF]

Front Neuroinform
Easmin R, Veronese M, Allen P, Nordio G, Turkheimer F.   +4 more
europepmc   +1 more source

The effect of online hygiene information expression on customers' institutional and cognitive trust in tourist accommodation. [PDF]

Front Public Health
Zhang B, Li Y, Fang X, Huang W, Meng Q.
europepmc   +1 more source