Results 171 to 180 of about 4,798 (280)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
XACML-based Verifiable Cloud Access Control Scheme
, 2013 针对当前传感器节点的计算能力有限以及云访问控制服务的信任问题，在传感器网络双云场景中，借鉴仲裁游戏模型的思陝，提出可验证的云访问控制模型。利用可扩展访问控制标示语言中决策值及策略组合算法的特点，设计针对单条策略及策略集的可验证云访问控制方案，使传感器节点能够以较小的计算代价和传输代价实现复杂的访问控制决策。在 Amazon EC2云平台上的实验结果证明，与传统的本地访问控制方案陒比，该方案能够以较高的效率保证云访问控制结果的可靠性。 The computing resource of the ...
司晓琳, 王鹏翩, 张立武
core
VeriFed: Temporally Consistent Continuous Cross-Chain Data Federation. [PDF]
Entropy (Basel)Hao K, Bi M, Ma Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
ON THE STRUCTURE OF VERIFIABLE CODE GENERATOR SPECIFICATIONS
, 1990 Giegerich R. ON THE STRUCTURE OF VERIFIABLE CODE GENERATOR SPECIFICATIONS. SIGPLAN NOTICES.
Giegerich, Robert
core
Backcasting the Trust Gap: A Strategic Road Map for Clinician Adoption of AI Diagnostics by 2040. [PDF]
J Med Internet ResYu Y.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On the equivalence between classically verifiable position verification and certified randomness. [PDF]
Nat CommunKaleoglu F +6 more
europepmc +1 more source