Results 81 to 90 of about 4,798 (280)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Crowd Verifiable Zero-Knowledge and End-to-End Verifiable Multiparty Computation [PDF]
, 2020 Auditing a secure multiparty computation (MPC) protocol entails the validation of the protocol transcript by a third party that is otherwise untrusted. In this work, we introduce the concept of end-to-end verifiable MPC (VMPC), that requires the validation to provide a correctness guarantee even in the setting that all servers, trusted setup primitives
Foteini Baldimtsi +3 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Privacy-Preserving Publicly Verifiable Databases
, 2022 Verifiable databases (VDB) enables the data owner to outsource a huge unencrypted database to the powerful but untrusted cloud such that any client could later retrieve the database and check whether the cloud returns valid records or not. To the best of
Wang Q(王强) +5 more
core
Communications of the ACM, 2013 To instill greater confidence in computations outsourced to the cloud, clients should be able to verify the correctness of the results returned. To this end, we introduce Pinocchio, a built system for efficiently verifying general computations while relying only on cryptographic assumptions.
Bryan Parno +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Scalable and Soundness Verifiable Outsourcing Computation in Marine Mobile Computing
, 2017 Outsourcing computation with verifiability is a merging notion in cloud computing, which enables lightweight clients to outsource costly computation tasks to the cloud and efficiently check the correctness of the result in the end.
Lifei Wei +3 more
core +1 more source
Verifiable access control scheme based on unpaired CP-ABE in fog computing
Tongxin xuebao, 2021 Fog computing extends computing power and data analysis applications to the edge of the network, solves the latency problem of cloud computing, and also brings new challenges to data security.Attribute encryption based on ciphertext strategy (CP-ABE) is ...
Jiangtao DONG, Peiwen YAN, Ruizhong DU
doaj +2 more sources
IEEE AccessEnsuring reproducibility and trustworthiness in intelligent systems has become a cornerstone of applied systems innovation. This study introduces HyCoSS++, a deterministic machine learning framework with simulated ledger-based audit anchoring that ...
Gabit Shuitenov +5 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source