Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Distorted Fingerprint Verification System [PDF]
Fingerprint verification is one of the most reliable personal identification methods. Fingerprint matching is affected by non-linear distortion introduced in fingerprint impression during the image acquisition process. This non-linear deformation changes
Jeyalatha SIVARAMAKRISHNAN +1 more
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
System verification : proving the design solution satisfies the requirements /
System Verification: Proving the Design Solution Satisfies the Requirements, Second Edition explains how to determine what verification work must be done, how the total task can be broken down into verification tasks involving six straightforward methods,
Grady, Jeffrey O.,author.
core
Digital divide in information verification among young seniors: An analysis of literacies and sociodemographic factors. [PDF]
PLoS OneYu W, Liu Y, Ngai CSB, Park J.
europepmc +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
An eclectic quadrant of rule based system verification: work grounded in verification of fuzzy rule bases. [PDF]
In this paper, we used a research approach based on grounded theory in order to classify methods proposed in literature that try to extend the verification of classical rule bases to the case of fuzzy knowledge modeling.
Vanthienen, Jan +3 more
core
The Verification Gap: Artificial Intelligence Adoption, Hallucination Awareness, and Verification Practices Among Medical Trainees and Professionals in Pakistan. [PDF]
CureusSajjad M, Mirza S, Sajjad A, Amer R.
europepmc +1 more source