Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Modeling Behavioral Determinants of Following and Verifying AI-Generated Health Advice: The Roles of eHealth Literacy, Cognitive Load, and Technology Self-Efficacy. [PDF]
J Multidiscip HealthcAlhur AA, Alnasser B.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Establishment of an intelligent auto-verification system for infectious serological markers in a clinical laboratory from West China. [PDF]
Medicine (Baltimore)Gou Y +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Adherence to Underage Alcohol Sales Regulations in the Republic of Cyprus: Evidence from Repeated Cross-Sectional Mystery Shopping Study. [PDF]
Nordisk Alkohol NarkManoli A +5 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Abstract Interpretation-based verification/certification in the ciaoPP system
, 2005 CiaoPP is the abstract interpretation-based preprocessor of the Ciao multi-paradigm (Constraint) Logic Programming system. It uses modular, incremental abstract interpretation as a fundamental tool to obtain information about programs.
Albert Albiol, Elvira +2 more
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Microsurgical Clip Reconstruction of Multiple Contiguous Aneurysms of the Anterior Communicating Artery Complex: Subfrontal Exposure and Endoscopic Verification-A Case Illustration. [PDF]
Neurosurg PractLiu H, Oberschachtsiek L, Muhammad S.
europepmc +1 more source