Results 171 to 180 of about 12,029,480 (253)

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1358-1367, June 2026.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin, Erik Kvam, Lisa Lowery, Nathan Hudson, Jenny Keen, Brian Davis, Roger B. Dodd, Christine Surrette, John Nelson   +8 more
wiley   +1 more source

Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines

Virology Journal
Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 infections.
Dongqing Zhang, Yuxiang Zou, Jiaying Wu, Longfa Xu, Zhifeng Ke, Yuanyuan Wu, Zhenhong Zhou, Mujin Fang, Ling Chen, Henggang Xu, Jianping Chu, Ningshao Xia, Rui Zhu, Tong Cheng   +13 more
doaj   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Nutritional, phytochemical, and potential health benefits of Monostroma spp.: A systematic review

Food Biomacromolecules, Volume 3, Issue 2, Page 252-272, June 2026.
Abstract Monostroma spp., belonging to the green seaweed, has been known to be health‐promoting food items as prophylactic agents worldwide. It has shown wide arrays of bioactivities for the prevention and treatment of various diseases. A total of 47 articles were selected to review following the Preferred Reporting Items for Systematic reviews and ...
Md Shariful Islam
wiley   +1 more source

Isolation of Mycoplasma genitalium from first-void urine specimens by coculture with Vero cells

, 2007
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Ryoichi Hamasuna, Yukio Osada, Vero Cells, Jørgen Skov Jensen   +3 more
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Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS‐CoV‐2 P.1 Variant in K18‐hACE2 Mice

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Introduction While severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been extensively studied in the context of pulmonary disease, its impact on metabolic organs remains poorly understood, particularly across experimental models.
Monara Kaélle Sérvulo Cruz Angelim, Patrícia Brito Rodrigues, Antônio Thiago Pereira Campos, Giovanni Freitas Gome, Gabriela Fabiano Souza, Valquíria Aparecida Matheus, Carlos Lenz Cesar, José Luiz Proença‐Módena, Marco Aurélio R. Vinolo, Pedro M. Moraes‐Vieira   +9 more
wiley   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Harnessing Trace Elements: Novel Radiosensitization Strategies for Enhanced Cancer Radiotherapy

Rare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Radiotherapy (RT) is one of the core methods of comprehensive cancer treatment. Globally, more than 40% of cancer patients rely on radiotherapy to achieve tumor control, cure or palliative relief. However, radiation resistance, immunosuppression and normal tissue injury limit its clinical application.
Yuhuan Zhang, Yizhi Ge, Hongguang Xiang, Ji Liu, Yu Tian, Yan Shen, Dan Zong   +6 more
wiley   +1 more source

Single cell dimulation and metabolic analysis of vero cells

, 2000
动物细胞大规模培养技术目前已经成为生物工程领域一个重要分支，但这一技术比较复杂，生产成本高，这在一定程度上限制了其自身的发展。目前国内外都在对动物细胞大规模培养技术进行更为广泛和深入的研究，研究方向多集中于宏观的反应和过程，而较少从细胞水平上对生长和代谢进行研究。大规模细胞培养中的宏观反应过程是以单个细胞为基础的，为了能够深入地了解细胞培养过程，更好地控制和优化这一过程，本文对单细胞的生长、代谢和模拟进行了研究，为动物细胞大规模培养技术的发展提供一些理论基础和实验数据 ...
高红亮
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