Results 131 to 140 of about 352,568 (281)

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Degradação de corantes e efluentes têxteis pela enzima Horseradish peroxidase (HRP) [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia QuímicaEste trabalho apresenta uma avaliação do potencial da enzima vegetal Horseradish peroxidase (HRP), para a descoloração de ...
Forgiarini, Eliane
core  

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Advertising; Versatile

Versatile Performance 4-wheel drive, literature on early models.
Lester F. Larsen Tractor Test and Power Museum
core  

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

De Novo Design and Structural Optimization of Mn(salen)‐Based Artificial Metalloenzymes for Asymmetric Sulfoxidation

Angewandte Chemie, EarlyView.
We report the computational design of de novo proteins that bind Mn(salen)‐based complexes (L1) using Rosetta FastDesign and verified by AlphaFold2. After screening, the catalytic activity for the promising design (dnMSBP) toward enantioselective sulfoxidation of thioanisole was optimized based on its crystal structure. With 10 different substrates, we
Jing‐Xiang Wang, Yunling Deng, Indrek Kalvet, Amira Haque, Huiguang Dai, David Baker, Yi Lu   +6 more
wiley   +2 more sources

Biodegradation of polycyclic aromatic hydrocarbons: The role of ligninolytic enzymes and advances of biosensors for in-situ monitoring

Emerging Contaminants
Polycyclic aromatic hydrocarbons (PAHs) and their derivatives are common pollutants that require effective remediation techniques. PAH biodegradation using bacterial and fungal enzymes has gained popularity because it effectively removes these ...
Eshet Lakew Tesfaye, Fekadu Mazengiaw Bogale, Tadele Assefa Aragaw   +2 more
doaj   +1 more source

Erratum to: High-yield production of manganese peroxidase, lignin peroxidase, and versatile peroxidase in Phanerochaete chrysosporium [PDF]

Applied Microbiology and Biotechnology, 2014
Nancy Coconi-Linares, Denis Magaña-Ortíz, Doralinda A. Guzmán-Ortiz, Francisco Fernández, Achim M. Loske, Miguel A. Gómez-Lim   +5 more
openaire   +1 more source