Results 81 to 90 of about 7,300,025 (237)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
La naturaleza. Versión psíquica [PDF]
, 1998 Se presentan los argumentos de una versión psíquica-por contraposición a una versión física- de la realidad material. Se establce un continuo, cuyos extremos están ocupados por objetos verficables de contornos definidos y por objetos que carecen de ...
Fernández Christlieb, Pablo
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
, 2016 Versión larga del vídeo Nuevas Masculinidadeshttp://www.ipas.org/es-MX/Where-We-Work/The-Americas/Bolivia ...
IPAS Bolivia
core
Transaction costs, externalities and innovation [PDF]
There is now considerable evidence on the value of using external resources to promote the development of innovative technologies. Furthermore, the ability to experience innovations in business by external links that may help to avoid risk, improve the ...
Estrada, Fernando, Diaz, Natalia
core +4 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
La versión extranjera [Reseña] [PDF]
, 2020 Reseña de: Florencia del Campo: La versión extranjera, Valencia, Pre-Textos ...
Botello, Carmen
core
Versión Digital EPUB (E-BOOK) [PDF]
, 2019 Versión Digital Tecnura Volumen 17 - Número ...
Tecnura, Revista
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source