Results 131 to 140 of about 42,330 (304)

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump   +8 more
wiley   +1 more source

“How to Measure the Outcome in the Treatment of Vertebral Compression Fractures? A Systematic Literature Review of Highly Cited Level-I Studies.” [PDF]

open access: green, 2021
Sonja Häckel   +6 more
openalex   +1 more source

Mitigating subtherapeutic cabozantinib exposure after prior mitotane therapy in adrenocortical carcinoma: Pharmacological boosting with cobicistat

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 606-611, February 2026.
Mitotane is an adrenolytic drug with cytotoxic effects, registered for the treatment of advanced adrenocortical carcinoma (ACC), a rare but aggressive tumour type with a poor prognosis despite treatment. Recently, the oral multi‐kinase inhibitor cabozantinib has shown promising results as a potential second‐line treatment option.
Annemieke M. Peters van Ton   +4 more
wiley   +1 more source

Biomechanical analysis of osteoporotic spines with diseases using CT-based finite element method [PDF]

open access: yes, 2016
The eventuality of recurrent fractures on the adjacent level of fractured vertebra is becoming prevalent in this era. To date, the underlying cause of this phenomena is either due to low bone quality or adverse geometrical changes of the vertebral body,
Mazlan, Muhammad Hazli
core  

Hypofractionated Radiation Therapy for Pain Relief of Patients With Spinal Metastasis: A Real‐World Analysis

open access: yesCancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Purpose Spinal metastases may cause pain, neurological compromise, paraplegia, and limb movement disorders; their management requires a comprehensive approach. Alongside systemic anti‐tumor therapies, focal interventions such as radiotherapy, bone‐modifying agents, and surgery are crucial for slowing disease progression and managing pain in ...
Lu Sun   +6 more
wiley   +1 more source

Skeletal malformations among the Clarias species from fish mongers in Ekiti State [PDF]

open access: yes, 2011
Clarias species purchased from fish mongers from Ado – Ekiti, Ikun Ekiti, Itapaji – Ekiti Nigeria were examined for possible deformities in any part of their body.
Fagbuaro , Omotayo, Oso, James Abayomi
core  

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

open access: yesComprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara   +12 more
wiley   +1 more source

Vertebral Compression Fractures after Lumbar Instrumentation.

open access: yesCureus, 2017
Lumbar spinal stenosis (LSS) is primarily found in an older population. This is a similar demographic group that develops both osteoporosis and vertebral compression fractures (VCF). This report reviewed a series of patients treated for VCF that had previous lumbar surgery for symptomatic spinal stenosis.
Granville, Michelle   +2 more
openaire   +2 more sources

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