Results 111 to 120 of about 416,381 (343)

Unlocking Lactonase Enzymes as Biocatalysts for the Deracemisation of Chiral γ‐Thiolactones

open access: yesAngewandte Chemie, EarlyView.
The application of lactonase enzymes as biocatalysts still remains underexplored. This study discloses the biocatalytic activity of two lactonases in the deracemisation of chiral C3‐substituted‐γ‐thiolactones. The biocatalyst GcL catalyses the enzymatic kinetic resolution (EKR) of C3‐amide‐thiolactones, while the rationally engineered biocatalyst N9 ...
Jingyue Wu   +7 more
wiley   +2 more sources

Evolutionary dynamics of olfactory receptor genes in chordates: interaction between environments and genomic contents

open access: yesHuman Genomics, 2009
Olfaction is essential for the survival of animals. Versatile odour molecules in the environment are received by olfactory receptors (ORs), which form the largest multigene family in vertebrates. Identification of the entire repertories of OR genes using
Niimura Yoshihito
doaj   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

open access: yesAdvanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai   +14 more
wiley   +1 more source

Evolution and Functional Diversification of the GLI Family of Transcription Factors in Vertebrates

open access: yesEvolutionary Bioinformatics, 2009
Background: In vertebrates the “SONIC HEDGEHOG” signalling pathway has been implicated in cell-fate determination, proliferation and the patterning of many different cell types and organs.
Amir Ali Abbasi   +3 more
doaj  

The evolution of vertebrate Toll-like receptors.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2005
The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis. Strong selective pressure for recognition of and response to pathogen-associated molecular
J. Roach   +7 more
semanticscholar   +1 more source

Subgenome Partitioning and Polyploid Genome Evolution in the Loach Family Botiidae (Order Cypriniformes)

open access: yesAdvanced Science, EarlyView.
This study investigates subgenome evolution and polyploidy in Cypriniformes fish, revealing complex phylogenetic relationships and genomic dynamics. By applying advanced subgenome partitioning methods, it uncovers novel insights into transposon activity and gene fractionation.
Yunyun Lv   +14 more
wiley   +1 more source

Multifunctional Framework Nucleic Acid Vehicle for Antibiotic Sensitization and Treatment of Methicillin‐Resistant Staphylococcus aureus

open access: yesAggregate, EarlyView.
A self‐assembling, aggregation‐enhanced tetrahedral DNA nanostructure (tFNA), termed TACs, enables localized accumulation and sustained release of ceftriaxone while co‐delivering antisense oligonucleotides that silence mecA, reduce PBP2a expression, and restore β‐lactam susceptibility in MRSA.
Yicheng Zhao   +10 more
wiley   +1 more source

Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future

open access: yesAdvanced Intelligent Systems, EarlyView.
Many discussions of artificial intelligence fail to address deeper questions being raised by advances in developmental biology, neuroscience, bioengineering, and philosophy of mind. Novel beings, including technologically and biologically augmented humans, engineered life forms, hybrots, and others, require tools of the emerging field of diverse ...
Michael Levin
wiley   +1 more source

Advances in Invertebrate Biohybrid Robotics: Leveraging Nature for Locomotion and Sensing in Engineered Systems

open access: yesAdvanced Intelligent Systems, EarlyView.
This review explores invertebrate biohybrid robots that integrate living organisms—such as insects, jellyfish, spiders, and sea slugs—into robotic systems for locomotion, sensing, and actuation. The advantages in efficiency and cost, discuss control, and power challenges are highlighted, and future considerations to guide the development of sustainable,
Charles J. Fraga   +2 more
wiley   +1 more source

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