Results 281 to 290 of about 416,381 (343)

Novel 4,5‐Dihydrothiazole‐Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

ChemMedChem, EarlyView.
The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła‐Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino   +18 more
wiley   +1 more source

Human, Animal, or Mineral? Ethical Considerations for Studies of Fossilized Hominin Remains. [PDF]

Am J Biol Anthropol
Champney TH, Smith HF, Hildebrandt S, Cornwall J.   +3 more
europepmc   +1 more source

Carbonate microfacies and transgressive‐regressive sequences of Oxfordian shallow‐water limestones (Korallenoolith, Lower Saxony Basin)

The Depositional Record, EarlyView.
The Bisperode section is one of the most expanded and complete sections with shallow‐marine Oxfordian strata in the LSB. This study provides a reference record for shallow‐marine settings and allows for the correlation of the strata from the LSB with Oxfordian deposits distributed elsewhere in the world.
Deyan Zhang, François‐Nicolas Krencker, Stefan Huck, Ulrich Heimhofer   +3 more
wiley   +1 more source

The Transcriptomic Signature of Donkey Ovarian Tissue Revealed by Cross-Species Comparative Analysis at Single-Cell Resolution. [PDF]

Animals (Basel)
Tian Y, Niu Y, Zhang X, Wang T, Tian Z, Zhang X, Guo J, Ge W, Liu S, Sun Y, Li J, Shen W, Wang J, Zhang T.   +13 more
europepmc   +1 more source

Conformational Regulation of Vertebrate γ‐Tubulin Ring Complexes by CM1 Proteins

Cytoskeleton, EarlyView.
Michal Wieczorek
wiley   +1 more source

An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate

Developmental Dynamics, EarlyView.
Abstract Background The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial surface of the neural plate as internalization begins to form the neural keel in the hindbrain region of the zebrafish embryo.
Claudio Araya, Raegan Boekemeyer, Francesca Farlie, Lauren Moon, Freshta Darwish, Chris Rookyard, Leanne Allison, Gema Vizcay‐Barrena, Roland Fleck, Millaray Aranda, Masa Tada, Jonathan D. W. Clarke   +11 more
wiley   +1 more source

The vertebrate small leucine-rich proteoglycans: amplification of a clustered gene family and evolution of their transcriptional profile in jawed vertebrates. [PDF]

G3 (Bethesda)
Gil N, Leurs N, Martinand-Mari C, Debiais-Thibaud M.   +3 more
europepmc   +1 more source

Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish

Developmental Dynamics, EarlyView.
Abstract Background Environmental influence is critical for embryogenesis but is significantly under‐appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on the developmental phenotype of zebrafish lacking the transcription factor Grainyhead‐like 3 (grhl3 ...
Nishanthi Mathiyalagan, Travis K. Johnson, Zachary Di Pastena, Jarrad N. Fuller, Lee B. Miles, Sebastian Dworkin   +5 more
wiley   +1 more source

Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds. [PDF]

Adv Biol (Weinh)
Morimoto J, Pietras Z.
europepmc   +1 more source

Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak, Karemna Barrera Jaimes, Minh Hanh Doan, Jordyn M. Chartrand, Matthew K. Vickaryous   +4 more
wiley   +1 more source