Results 71 to 80 of about 247,288 (294)

Retinal oxygen supply shaped the functional evolution of the vertebrate eye

eLife, 2019
The retina has a very high energy demand but lacks an internal blood supply in most vertebrates. Here we explore the hypothesis that oxygen diffusion limited the evolution of retinal morphology by reconstructing the evolution of retinal thickness and the
Christian Damsgaard, Henrik Lauridsen, Anette MD Funder, Jesper S Thomsen, Thomas Desvignes, Dane A Crossley II, Peter R Møller, Do TT Huong, Nguyen T Phuong, H William Detrich III, Annemarie Brüel, Horst Wilkens, Eric Warrant, Tobias Wang, Jens R Nyengaard, Michael Berenbrink, Mark Bayley   +16 more
doaj   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

A game of substrates: replication fork remodeling and its roles in genome stability and chemo-resistance

Cell Stress, 2017
During the hours that human cells spend in the DNA synthesis (S) phase of the cell cycle, they may encounter adversities such as DNA damage or shortage of nucleotides.
Julia Sidorova
doaj   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Molecular Models for Vertebrate Limb Development [PDF]

, 1997
Randy L. Johnson, Clifford J. Tabin
openalex   +1 more source

Erratum: Roadkills in Northern Peninsular Malaysia

Frontiers in Environmental Science, 2022
Frontiers Production Office
doaj   +1 more source

A Microfluidic Digital Shutter of Liquid–Liquid Interface for Fabrication of Multifaceted Hydrogel Microfiber Structure

Advanced Science, EarlyView.
A programmable passive digital shutter based on multiphase liquid–liquid interface dynamics is introduced for precise fabrication of hydrogel microfibers. By modulating the shutter operation, microfibers with tunable geometry—including linear, helical, tadpole‐like, and spherical forms—are produced.
Dongrui Zhang, Jiangyue Liu, Hao Ye, Yu Shen, Haoran Su, Zhuqing Liang, Kexin Li, Xing Zhang, Shiyi Yang, Yunfei Lu, Zhexi Zhang, Sihang Liu, Yi Huang, Xiao Liu, Yubo Fan   +14 more
wiley   +1 more source

Retroviral enhancer detection insertions in zebrafish combined with comparative genomics reveal genomic regulatory blocks - a fundamental feature of vertebrate genomes [PDF]

, 2007
Hiroshi Kikuta, David Fredman, Silke Rinkwitz, Boris Lenhard, Thomas Becker   +4 more
openalex   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Kiss-and-Run Is a Significant Contributor to Synaptic Exocytosis and Endocytosis in Photoreceptors

Frontiers in Cellular Neuroscience, 2017
Accompanying sustained release in darkness, rod and cone photoreceptors exhibit rapid endocytosis of synaptic vesicles. Membrane capacitance measurements indicated that rapid endocytosis retrieves at least 70% of the exocytotic membrane increase.
Xiangyi Wen, Xiangyi Wen, Grant W. Saltzgaber, Wallace B. Thoreson, Wallace B. Thoreson   +4 more
doaj   +1 more source