Results 41 to 50 of about 6,525 (155)

Verteporfin Inhibits Severe Fever with Thrombocytopenia Syndrome Virus Infection via Inducing the Degradation of the Viral Gn Protein

Pharmaceutics
Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus, causing the hemorrhagic infectious disease of SFTS, with a case fatality rate up to 30% due to the absence of effective therapeutic interventions ...
Bingan Wu, Chenyang Yu, Yuxiang Lin, Ping Zhao, Zhongtian Qi, Xijing Qian   +5 more
doaj   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, Volume 4, Issue 2, June 2026.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Verteporfin Suppresses YAP-Induced Glycolysis in Breast Cancer Cells

Journal of Investigative Surgery, 2023
Objective The inhibition of the Hippo pathway through targeting the Yes-associated protein (YAP) presents a novel and promising approach for treating tumors.
Hong Chen, Ling-Fei Zhang, Ying Miao, Yun Xi, Xuefei Li, Mo-Fang Liu, Min Zhang, Biao Li   +7 more
doaj   +1 more source

Delivering Proteins and Enzymes to Solid Tumors Through the Development of Stimuli‐Responsive Nanocarriers

ChemNanoMat, Volume 12, Issue 6, June 2026.
Stimuli‐responsive strategies to achieve controlled release of protein‐based therapeutic agents into solid tumors. Proteins, enzymes, and peptides have long been recognized as valuable therapeutic agents, particularly in oncology. However, their complex chemical structures render them more sensitive than smaller chemotherapeutic drugs.
Guillermo Plaza‐Palomo, Diana Benita‐Donadios, Sandra Jiménez‐Falcao, Alejandro Baeza   +3 more
wiley   +1 more source

Quercetin Inhibits Orthodontic Tooth Movement‐Associated Periodontitis by Regulating Macrophage Aerobic Glycolysis Through the IL‐17/Hippo/YAP Axis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Orthodontic tooth movement (OTM) is frequently accompanied by inflammatory responses, including periodontitis, which may compromise treatment outcomes. This study investigated the protective role of quercetin, a natural flavonoid, in OTM‐associated periodontitis and its underlying mechanism involving macrophage metabolic ...
Fen Yao, Zhiping Song, Wuchao Wu, Bingqian Liu, Rongqi Xia, Yao Zhou, Wenxia Wang, Yujie Chen, Zhengyu Liao   +8 more
wiley   +1 more source

Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in
Gloria Garoffolo, Thijs J. Sluiter, Anita Thomas, Luca Piacentini, Matthijs S. Ruiter, Alessia Schiavo, Massimo Salvi, Claudio Saccu, Stefano Zoli, Mattia Chiesa, Takumi Yokoyama, Marco Agrifoglio, Monica Soncini, Gianfranco B. Fiore, Fabio Martelli, Gianluigi Condorelli, Paolo Madeddu, Filippo Molinari, Umberto Morbiducci, Paul H. A. Quax, Gaia Spinetti, Margreet R. de Vries, Maurizio Pesce   +22 more
doaj   +1 more source

The Role of Photoactivated and Non-Photoactivated Verteporfin on Tumor

Frontiers in Pharmacology, 2020
Verteporfin (VP) has long been clinically used to treat age-related macular degeneration (AMD) through photodynamic therapy (PDT). Recent studies have reported a significant anti-tumor effect of VP as well.
Changran Wei, Xiangqi Li, Xiangqi Li
doaj   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Theranostic Verteporfin-Conjugated Upconversion Nanoparticles for Cancer Treatment

Nanomaterials
Photodynamic therapy (PDT) is a highly selective, clinically approved, minimally invasive technique that effectively eliminates cancer cells.
Oleksandr Shapoval, Vitalii Patsula, David Větvička, Miroslav Šlouf, Martina Kabešová, Taras Vasylyshyn, Ludmila Maffei Svobodová, Magdalena Konefal, Olga Kočková, Jan Pankrác, Petr Matouš, Vít Herynek, Daniel Horák   +12 more
doaj   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source