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The Hippo Pathway and Viral Infections [PDF]
Frontiers in Microbiology, 2020 The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang +5 more
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Premetazoan Origin of the Hippo Signaling Pathway
Cell Reports, 2012 Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of
Arnau Sebé-Pedrós +3 more
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Frontiers in Oncology, 2023 BackgroundThe activation of YAP/TAZ transcriptional co-activators, downstream effectors of the Hippo/YAP pathway, is commonly observed in human cancers, promoting tumor growth and invasion.
Yu-Duo Guo +5 more
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Disease implication of hyper-Hippo signalling [PDF]
Open Biology, 2016 The Hippo signalling pathway regulates cellular proliferation, apoptosis and differentiation, thus exerting profound effects on cellular homeostasis. Inhibition of Hippo signalling has been frequently implicated in human cancers, indicating a well-known ...
Shu-Ping Wang, Lan-Hsin Wang
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The Hippo signalling pathway and its implications in human health and diseases
Signal Transduction and Targeted Therapy, 2022 As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in the regulation of numerous biological processes. Thus, substantial efforts have been made to understand the upstream signals that influence the activity of the ...
Minyang Fu +5 more
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The Hippo pathway uses different machinery to control cell fate and organ size
iScience, 2021 Summary: The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in the Drosophila eye, where Hippo specifies whether cells sense blue or green light.
Jonathan M. Pojer +4 more
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The critical role of the Hippo signaling pathway in kidney diseases
Frontiers in Pharmacology, 2022 The Hippo signaling pathway is involved in cell growth, proliferation, and apoptosis, and it plays a key role in regulating organ size, tissue regeneration, and tumor development.
Yuting Sun +9 more
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Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
Cells, 2021 Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated
Yvonne Xinyi Lim +3 more
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Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.
PLoS Genetics, 2021 The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanogaster eye, the Hippo pathway controls the fate choice between one of two subtypes that express either the blue light ...
Jonathan M Pojer +3 more
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The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response
Frontiers in Immunology, 2022 The Hippo pathway was initially discovered in Drosophila melanogaster and mammals as a key regulator of tissue growth both in physiological and pathological states. Numerous studies depict the vital role of the Hippo pathway in cardiovascular development,
Ancheng Zheng, Qishan Chen, Li Zhang
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