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The Hippo signalling pathway and its implications in human health and diseases
Signal Transduction and Targeted Therapy, 2022 As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in the regulation of numerous biological processes. Thus, substantial efforts have been made to understand the upstream signals that influence the activity of the ...
Minyang Fu +5 more
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The Hippo Pathway and Viral Infections [PDF]
Frontiers in Microbiology, 2020 The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have discovered that the Hippo signaling pathway plays a critical role in a wide range of biological processes, including organ size control ...
Zhilong Wang +5 more
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Premetazoan Origin of the Hippo Signaling Pathway
Cell Reports, 2012 Nonaggregative multicellularity requires strict control of cell number. The Hippo signaling pathway coordinates cell proliferation and apoptosis and is a central regulator of organ size in animals. Recent studies have shown the presence of key members of
Arnau Sebé-Pedrós +3 more
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The Hippo Pathway: Biology and Pathophysiology [PDF]
Annual Review of Biochemistry, 2019 The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, and regeneration.
Shenghong, Ma +3 more
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Hippo signaling pathway and respiratory diseases
Cell Death Discovery, 2022 The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, and regeneration.
Weifeng Tang +7 more
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Hippo Signaling Pathway in Gliomas [PDF]
Cells, 2021 The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits
Konstantin Masliantsev +2 more
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Frontiers in Oncology, 2023 BackgroundThe activation of YAP/TAZ transcriptional co-activators, downstream effectors of the Hippo/YAP pathway, is commonly observed in human cancers, promoting tumor growth and invasion.
Yu-Duo Guo +5 more
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Disease implication of hyper-Hippo signalling [PDF]
Open Biology, 2016 The Hippo signalling pathway regulates cellular proliferation, apoptosis and differentiation, thus exerting profound effects on cellular homeostasis. Inhibition of Hippo signalling has been frequently implicated in human cancers, indicating a well-known ...
Shu-Ping Wang, Lan-Hsin Wang
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Cold Spring Harbor Perspectives in Biology, 2012 The Hippo pathway regulates tissue growth, and inactivation of any of four key components (HPO, WTS, SAV, and MATS) results in tissue overgrowth. Cell junctions may also modulate the pathway's activity.
Kieran F, Harvey, Iswar K, Hariharan
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The Hippo pathway uses different machinery to control cell fate and organ size
iScience, 2021 Summary: The Hippo pathway is a conserved signaling network that regulates organ growth and cell fate. One such cell fate decision is that of R8 photoreceptor cells in the Drosophila eye, where Hippo specifies whether cells sense blue or green light.
Jonathan M. Pojer +4 more
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