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The Hippo Pathway in Kidney Development. [PDF]
Encyclopedia (BaselThe kidney, a complex organ crucial for a multitude of homeostatic functions, including the maintenance of fluid and electrolyte balance, removal of various metabolic waste products, and hormone production, undergoes intricate developmental processes to form functional nephron units.
Lara CM +4 more
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Targeting the Hippo Pathway for Cardiac Regeneration. [PDF]
Physiology (Bethesda)Ischemic heart disease, which affects more than 200 million people worldwide, is caused by reduced blood flow to the heart and leads to widespread cardiomyocyte death. Due to the limited regenerative potential of cardiomyocytes, the lost tissue is replaced by a fibrotic scar, resulting in reduced cardiac function and progression to heart failure ...
Li RG, Meng F, Martin JF.
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The role of the Hippo pathway in melanocytes and melanoma [PDF]
Frontiers in Oncology, 2013 The Hippo signalling pathway comprises a series of cytoplasmic tumour suppressor proteins including Merlin and the Lats1/2 and MST1/2 kinases, and is thought to play a critical role in determining the sizes of organs and tissues.
Bruce Charles Baguley +2 more
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Cold Spring Harbor Perspectives in Biology, 2012 The Hippo pathway regulates tissue growth, and inactivation of any of four key components (HPO, WTS, SAV, and MATS) results in tissue overgrowth. Cell junctions may also modulate the pathway's activity.
Kieran F, Harvey, Iswar K, Hariharan
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The Hippo Pathway: Immunity and Cancer [PDF]
Cancers, 2018 Since its discovery, the Hippo pathway has emerged as a central signaling network in mammalian cells. Canonical signaling through the Hippo pathway core components (MST1/2, LATS1/2, YAP and TAZ) is important for development and tissue homeostasis while aberrant signaling through the Hippo pathway has been implicated in multiple pathologies, including ...
Zaid Taha +2 more
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What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans? [PDF]
Journal of Biochemistry, 2013 The Hippo pathway was originally identified in Drosophila as the signalling pathway that governs organ size. The core of the pathway harbours two protein kinases (Hippo and Warts). Hippo phosphorylates and activates Warts, which in turn phosphorylates and inactivates the transcriptional co-activator Yorkie.
Zeyu, Yang, Yutaka, Hata
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Hippo Signaling Pathway in Gliomas [PDF]
Cells, 2021 The Hippo signaling pathway is a highly conserved pathway involved in tissue development and regeneration that controls organ size through the regulation of cell proliferation and apoptosis. The core Hippo pathway is composed of a block of kinases, MST1/2 (Mammalian STE20-like protein kinase 1/2) and LATS1/2 (Large tumor suppressor 1/2), which inhibits
Konstantin Masliantsev +2 more
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The Hippo Pathway: Biology and Pathophysiology [PDF]
Annual Review of Biochemistry, 2019 The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, and regeneration.
Shenghong, Ma +3 more
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The Hippo pathway, p53 and cholesterol [PDF]
Cell Cycle, 2016 ASBTRACT Increased rates of cholesterol and lipid synthesis have long been recognized as important aspects of the metabolic rewiring that occurs during cancerous transformation. Many genes encoding enzymes involved in cholesterol and fatty acid biogenesis are transcriptional targets of the sterol regulatory element-binding proteins (SREBPs). The SREBPs
Yael, Aylon, Moshe, Oren
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YAP and the Hippo pathway in cholangiocarcinoma [PDF]
Journal of Gastroenterology, 2019 Cholangiocarcinoma (CCA) has an increasing incidence and remains a difficult to treat malignancy. In a search for more effective treatment options, progress has been made in identifying molecular drivers of oncogenic signaling including IDH mutations and FGFR2 fusions.
Takaaki Sugihara +3 more
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