Results 1 to 10 of about 320,341 (266)
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
Cell Reports, 2021 Summary: Cell death provides host defense and maintains homeostasis. Zα-containing molecules are essential for these processes. Z-DNA binding protein 1 (ZBP1) activates inflammatory cell death, PANoptosis, whereas adenosine deaminase acting on RNA 1 ...
Rajendra Karki +2 more
exaly +3 more sources
Frontiers in Pharmacology, 2023 Aberrant mitophagy has been identified as a driver for energy metabolism disorder in most cardiac pathological processes. However, finding effective targeted agents and uncovering their precise modulatory mechanisms remain unconquered.
Ji-Chao Zhou +20 more
doaj +1 more source
Crosstalk between ferroptosis and stress—Implications in cancer therapeutic responses
Cancer Innovation, 2022 Ferroptosis is a newly discovered form of cell death that is characterized by the accumulation of iron‐dependent lipid peroxidation. Research on ferroptosis has seen exponential growth over the past few years.
Cheng Zhang +6 more
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TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target
Acta Pharmaceutica Sinica B, 2021 Pulmonary fibrosis (PF) is a chronic, progressive, fatal interstitial lung disease with limited available therapeutic strategies. We recently reported that the protein kinase glycogen synthase kinase-3β (GSK-3β) interacts with and inactivates the ...
Shanshan Liu +12 more
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Control of cell death/survival balance by the MET dependence receptor
eLife, 2020 Control of cell death/survival balance is an important feature to maintain tissue homeostasis. Dependence receptors are able to induce either survival or cell death in presence or absence of their ligand, respectively. However, their precise mechanism of
Leslie Duplaquet +13 more
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Protein acylation: mechanisms, biological functions and therapeutic targets
Signal Transduction and Targeted Therapy, 2022 Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases.
Shuang Shang, Jing Liu, Fang Hua
doaj +1 more source
Bone Metastasis: Current State of Play
Translational Oncology, 2020 Bone metastasis (BM) in cancer remains a critical issue because of its associated clinical and biological complications. Moreover, BM can alter the quality of life and survival rate of cancer patients.
Anthony Turpin +2 more
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Hypoxia in Solid Tumors: How Low Oxygenation Impacts the “Six Rs” of Radiotherapy
Frontiers in Endocrinology, 2021 Radiotherapy is an important component of cancer treatment, with approximately 50% of all cancer patients receiving radiation therapy during their course of illness.
Andria Rakotomalala +11 more
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ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
Breast Cancer Research, 2018 Background The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer.
Mandy Dumortier +8 more
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SMARCA5 interacts with NUP98-NSD1 oncofusion protein and sustains hematopoietic cells transformation
Journal of Experimental & Clinical Cancer Research, 2022 Background Acute myeloid leukemia (AML) is characterized by accumulation of aberrantly differentiated hematopoietic myeloid progenitor cells. The karyotyping-silent NUP98-NSD1 fusion is a molecular hallmark of pediatric AML and is associated with the ...
Zivojin Jevtic +10 more
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