Results 21 to 30 of about 393,410 (301)

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse

Scientific Reports, 2018
The transcription factor C/EBPβ regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPβ protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start ...
Valérie Bégay, Christian Baumeier, Karin Zimmermann, Arnd Heuser, Achim Leutz   +4 more
doaj   +1 more source

Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model

Cell Reports, 2013
The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in several cancers.
Falk Saupe, Anja Schwenzer, Yundan Jia, Isabelle Gasser, Caroline Spenlé, Benoit Langlois, Martial Kammerer, Olivier Lefebvre, Ruslan Hlushchuk, Tristan Rupp, Marija Marko, Michael van der Heyden, Gérard Cremel, Christiane Arnold, Annick Klein, Patricia Simon-Assmann, Valentin Djonov, Agnès Neuville-Méchine, Irene Esposito, Julia Slotta-Huspenina, Klaus-Peter Janssen, Olivier de Wever, Gerhard Christofori, Thomas Hussenet, Gertraud Orend   +24 more
doaj   +1 more source

Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis

Frontiers in Cardiovascular Medicine, 2022
Recently, the extracellular matrix protein agrin has been reported to promote tumor angiogenesis that supports tumorigenesis and metastasis; however, there is a lack of in vivo genetic evidence to prove whether agrin derived from the tumors or ...
Peng Ye, Zelong Fu, Jeff Yat-Fai Chung, Xiaoyun Cao, Ho Ko, Ho Ko, Xiao Yu Tian, Patrick Ming-Kuen Tang, Kathy O. Lui, Kathy O. Lui, Kathy O. Lui   +10 more
doaj   +1 more source

Targets of Raf in tumorigenesis [PDF]

Carcinogenesis, 2010
Some 25 years ago, Raf was discovered as the transforming principle shared by a murine sarcoma and an avian carcinoma virus. Thus, Raf and tumorigenesis have been connected from the very beginning. Ten years later, the work of many groups instated Raf as the link between Ras, the oncogene most frequently mutated in human cancers, and the mitogen ...
Théodora S, Niault, Manuela, Baccarini
openaire   +3 more sources

Deciphering the Immune–Tumor Interplay During Early-Stage Lung Cancer Development via Single-Cell Technology

Frontiers in Oncology, 2022
Lung cancer is the leading cause of cancer-related death worldwide. Cancer immunotherapy has shown great success in treating advanced-stage lung cancer but has yet been used to treat early-stage lung cancer, mostly due to lack of understanding of the ...
Wei-Wei Chen, Wei Liu, Yingze Li, Jun Wang, Yijiu Ren, Guangsuo Wang, Chang Chen, Hanjie Li   +7 more
doaj   +1 more source

Tumorigenesis- and metastasis-associated PAN-ECM genes and their expressions inGP6 signaling pathway which were generated using QIAGEN’s Ingenuity® Pathway Analysis (IPA®, QIAGEN Redwood City) Software (27).

, 2020
Typical EC related tumorigenesis- and metastasis-associated PAN-ECM genes were identified. Most of them were collage-related genes and were downregulated in tumorigenesis and upregulated in metastasis of EC.
Vijesh Kumar Yadav (8742048), Justin Bo-Kai Hsu (8742051), Tzong-Yi Lee (10134), Hsien-Da Huang (1748), Tzu-Hao Chang (19304), Wei-Chung Vivian Yang (2063686)   +5 more
core   +1 more source

TREM-1 promotes intestinal tumorigenesis. [PDF]

, 2017
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses. Increasing evidence suggests a role for TREM-1 not only in acute pathogen-induced reactions but also in chronic and non ...
Lukas Mager, Müller, Christoph, Saurer, Leslie, Krebs, Philippe, Matteo Gusberti, Zlobec, Inti, Alessandro Lugli, Silvia Rihs, Simillion, Cedric, Gusberti, Matteo, Inti Zlobec, Rihs, Silvia, Christoph Mueller, Lugli, Alessandro, Daniel Zysset, Leslie Saurer, Cedric Simillion, Zysset, Daniel, Philippe Krebs, Mager, Lukas   +19 more
core   +2 more sources

Optogenetic investigation of BMP target gene expression diversity

eLife, 2020
Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis.
Katherine W Rogers, Mohammad ElGamacy, Benjamin M Jordan, Patrick Müller   +3 more
doaj   +1 more source

Evolutionary reversion in tumorigenesis

Frontiers in Oncology, 2023
Cells forming malignant tumors are distinguished from those forming normal tissues based on several features: accelerated/dysregulated cell division, disruption of physiologic apoptosis, maturation/differentiation arrest, loss of polarity, and invasive potential.
Yosuke Nagahata, Hiroshi Kawamoto
openaire   +3 more sources

Cep55 overexpression promotes genomic instability and tumorigenesis in mice [PDF]

, 2020
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal ...
Khanna, KK, Finnie, John. W., Nanayakkara, D, Bain, Amanda L, Burgess, Andrew, Duijf, PHG, Smits, VAJ, Nanayakkara, Devathri, Nag, P, Wall, M, Raninga, Prahlad, Kalimutho, Murugan, Burgess, A., Wall, M., Smits, Veronique AJ, Finnie, J.W., Wall, Meaghan, Burgess, A, Duijf, Pascal H. G., Sinha, D., Smits, Veronique A. J., Nanayakkara, D., Duijf, Pascal HG, Bain, Amanda L., Kalimutho, M., Kalimutho, M, Sinha, Debottam, Raninga, P., Finnie, JW, Nag, P., Subramanian, Goutham, Raninga, P, Subramanian, G., Khanna, Kum Kum, Duijf, P.H.G., Sinha, D, Nag, Purba, Subramanian, G, Smits, V.A.J., Bain, AL, Bain, A.L., Khanna, K.K., Finnie, John W   +42 more
core   +1 more source