Results 21 to 30 of about 320,341 (266)
Endothelial Agrin Is Dispensable for Normal and Tumor Angiogenesis
Frontiers in Cardiovascular Medicine, 2022 Recently, the extracellular matrix protein agrin has been reported to promote tumor angiogenesis that supports tumorigenesis and metastasis; however, there is a lack of in vivo genetic evidence to prove whether agrin derived from the tumors or ...
Peng Ye +10 more
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Frontiers in Oncology, 2022 Lung cancer is the leading cause of cancer-related death worldwide. Cancer immunotherapy has shown great success in treating advanced-stage lung cancer but has yet been used to treat early-stage lung cancer, mostly due to lack of understanding of the ...
Wei-Wei Chen +7 more
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Cells, 2019 Background: The role of regulatory T cells (Tregs) is now well established in the progression of hepatocellular carcinoma (HCC) linked to Hepatitis C virus (HCV) infection. However, nothing is known about the potential interplay between Tregs and HCV. In
Laurissa Ouaguia +8 more
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Optogenetic investigation of BMP target gene expression diversity
eLife, 2020 Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis.
Katherine W Rogers +3 more
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Nature Communications, 2016 It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence
Joe Nassour +13 more
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Frontiers in Cell and Developmental Biology, 2022 Hepatocellular carcinoma (HCC) is a common primary liver cancer with ∼750,000 annual incidence rates globally. PGE2, usually known as a pro-inflammatory cytokine, is over-expressed in various human malignancies including HCC.
Chao Chen +4 more
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Inflammasomes and intestinal tumorigenesis [PDF]
Drug Discovery Today: Disease Mechanisms, 2011 Colorectal cancer is a major health problem in developed countries. Chronic intestinal inflammation predisposes individuals to the development of colorectal cancer. The intracellular NOD-like receptors (NLRs) have emerged as crucial regulators of intestinal inflammation and colorectal tumorigenesis.
Md Hasan, Zaki +2 more
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The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo
International Journal of Cell Biology, 2011 The mammary gland is a unique organ that continually undergoes postnatal developmental changes. In mice, the mammary gland is formed via signals from terminal end buds, which direct ductal growth and elongation.
Karen M. Bussard, Gilbert H. Smith
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Evaluation of LRIG1 Expression in Larynx Pathologies
The Turkish Journal of Ear Nose and Throat, 2022 Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found.
Yavuz Gündoğdu +6 more
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DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
Neoplasia: An International Journal for Oncology Research, 2017 DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4.
Nanda Kumar Sasi +4 more
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