Results 21 to 30 of about 396,195 (253)

Cep55 overexpression promotes genomic instability and tumorigenesis in mice [PDF]

, 2020
High expression of centrosomal protein CEP55 has been correlated with clinico-pathological parameters across multiple human cancers. Despite significant in vitro studies and association of aberrantly overexpressed CEP55 with worse prognosis, its causal ...
Khanna, KK, Finnie, John. W., Nanayakkara, D, Bain, Amanda L, Burgess, Andrew, Duijf, PHG, Smits, VAJ, Nanayakkara, Devathri, Nag, P, Wall, M, Raninga, Prahlad, Kalimutho, Murugan, Burgess, A., Wall, M., Smits, Veronique AJ, Finnie, J.W., Wall, Meaghan, Burgess, A, Duijf, Pascal H. G., Sinha, D., Smits, Veronique A. J., Nanayakkara, D., Duijf, Pascal HG, Bain, Amanda L., Kalimutho, M., Kalimutho, M, Sinha, Debottam, Raninga, P., Finnie, JW, Nag, P., Subramanian, Goutham, Raninga, P, Subramanian, G., Khanna, Kum Kum, Duijf, P.H.G., Sinha, D, Nag, Purba, Subramanian, G, Smits, V.A.J., Bain, AL, Bain, A.L., Khanna, K.K., Finnie, John W   +42 more
core   +1 more source

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

Nature Communications, 2016
It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence
Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie   +13 more
doaj   +1 more source

Hepatitis C Virus Improves Human Tregs Suppressive Function and Promotes Their Recruitment to the Liver

Cells, 2019
Background: The role of regulatory T cells (Tregs) is now well established in the progression of hepatocellular carcinoma (HCC) linked to Hepatitis C virus (HCV) infection. However, nothing is known about the potential interplay between Tregs and HCV. In
Laurissa Ouaguia, Olivier Moralès, Lynda Aoudjehane, Czeslaw Wychowski, Abhishek Kumar, Jean Dubuisson, Yvon Calmus, Filomena Conti, Nadira Delhem   +8 more
doaj   +1 more source

The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo

International Journal of Cell Biology, 2011
The mammary gland is a unique organ that continually undergoes postnatal developmental changes. In mice, the mammary gland is formed via signals from terminal end buds, which direct ductal growth and elongation.
Karen M. Bussard, Gilbert H. Smith
doaj   +1 more source

DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways

Neoplasia: An International Journal for Oncology Research, 2017
DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4.
Nanda Kumar Sasi, Arjun Bhutkar, Nathan J. Lanning, Jeffrey P. MacKeigan, Michael Weinreich   +4 more
doaj   +1 more source

Chlamydia trachomatis as a Current Health Problem: Challenges and Opportunities

Diagnostics, 2022
Chlamydia is one of the most common sexually transmitted bacterial infections (STIs) worldwide. It is caused by Chlamydia trachomatis (CT), which is an obligate intracellular bacterium.
Rafaela Rodrigues, Carlos Sousa, Nuno Vale   +2 more
doaj   +1 more source

Epithelial NAIPs protect against colonic tumorigenesis. [PDF]

, 2015
NLR family apoptosis inhibitory proteins (NAIPs) belong to both the Nod-like receptor (NLR) and the inhibitor of apoptosis (IAP) families. NAIPs are known to form an inflammasome with NLRC4, but other in vivo functions remain unexplored.
Velin, D., Bega, H., Yu, C.W., Tardivel, Aubry, Michel H. Maillard, Ramanjaneyulu Allam, Chennupati, Vijaykumar, Chi Wang Yu, Hristina Bega, Aubry Tardivel, Maillard, M.H., Maillard, Michel H, Velin, Dominique, Maslowski, K.M., Maslowski, Kendle M, Chennupati, V., Pascal Schneider, Allam, R., Tardivel, A., Yu, Chi Wang, Bega, Hristina, Schneider, P., Dominique Velin, Allam, Ramanjaneyulu, Schneider, Pascal, Vijaykumar Chennupati, Maslowski, Kendle M; id_orcid, Kendle M. Maslowski   +27 more
core   +2 more sources

Microbial metabolites in colorectal tumorigenesis and cancer therapy

Gut Microbes, 2023
Trillions of microbes are indigenous to the human gastrointestinal tract, together forming an ecological community known as the gut microbiota. The gut microbiota is involved in dietary digestion to produce various metabolites.
Yali Liu, Harry Cheuk-Hay Lau, Jun Yu
doaj   +1 more source

Trinity of inflammation, innate immune cells and cross-talk of signalling pathways in tumour microenvironment

Frontiers in Pharmacology, 2023
Unresolved inflammation is a pathological consequence of persistent inflammatory stimulus and perturbation in regulatory mechanisms. It increases the risk of tumour development and orchestrates all stages of tumorigenesis in selected organs.
Ali Attiq, Sheryar Afzal
doaj   +1 more source

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

EMBO Molecular Medicine, 2017
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly ...
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas   +20 more
doaj   +1 more source