Results 31 to 40 of about 396,195 (253)

Gene methylation of human ovarian carcinoma stromal progenitor cells promotes tumorigenesis

, 2017
Background: This study aimed to investigate whether the DNA methylation of human ovarian carcinoma stromal progenitor cells (OCSPCs) could promote the tumorigenesis of ovarian carcinoma.
鄭文芳, Ho, Chih-Ming;Shih, Daniel Tzu-bi;Hsiao, Chih-Chiang;Huang, Shih-Hung;Chang, Shwu-Fen;Cheng, Wen-Fang   +1 more
core   +1 more source

Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo [PDF]

, 2010
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele
Newton, Ian P., Jarnicki, Andrew G., Nathke, Inke S.; id_orcid, Sansom, Owen, Nathke, I., Samuel, M., Suzuki, Hiromu, Tosh, David, Abud, H E, Newton, IP, Huelsken, J, Stacker, SA, Samuel, M S, Buchert, M, Ernst, M., Stacker, Steven, Stacker, S., Dimitris Athineos, Alan R Clarke, Newton Ian P., Helen E. Abud, Heath, JK, Abud Helen E., Clarke Alan R., Suzuki, H., Faux, Maree, Newton, I., Jarnicki, A.G., Meniel, VS, Michael Buchert, Ernst, Matthias, Sansom, Owen J., Sansom Owen J., Meniel, Valerie, Clarke, Alan R., Burke, Z D, Ian P Newton, Inke S Näthke, David Tosh, Näthke, I.S., Winbanks, Catherine, Ian P. Newton, Sansom, O J, Burke, Z., Samuel Michael S., Samuel, M.S., Näthke Inke S., Inke S. Näthke, Jarnicki, A G, Abud, H.E., Tosh, D, Burke, ZD, Catherine E Winbanks, Samuel, Michael S., Heath Joan K., Andrew G Jarnicki, Nusse, R., Jarnicki, Andrew, Meniel, V.S., Abud, H., Samuel, MS, Joan K Heath, Winbanks, C E, Clarke, A R, Winbanks, C.E., Suzuki Hiromu, Winbanks Catherine E., Clarke, Alan Richard, Clarke, A.R., Joerg Huelsken, Stacker, Steven A., Helen E Abud, Alan R. Clarke, Buchert, M., Owen J. Sansom, Abud, HE, Joan K. Heath, Faux Maree C., Jarnicki, AG, Owen J Sansom, Athineos Dimitris, Suzuki, H, Faux, M., Winbanks, C., Matthias Ernst, Huelsken Joerg, Athineos, D, Sansom, O.J., Burke, Zoe D., Meniel Valerie S., Huelsken, J., Tosh David, Newton, I.P., Samuel, Michael, Athineos, Dimitris, Ernst Matthias, Jarnicki Andrew G., Zoe D Burke, Stacker, S.A., Stacker, S A, Clarke, Alan, Buchert, Michael, Abud, Helen E., Michael S. Samuel, Jarnicki, A., Steven A Stacker, Meniel, Valerie S., Faux, M C, Athineos, D., Meniel, V., Ernst, M, Michael S Samuel, Heath, Joan K., Nathke, I S, Sansom, OJ, Newton, Ian, Tosh, D., Valerie S. Meniel, Clarke, AR, Newton, I P, Näthke, Inke S., Meniel, V S, Valerie S Meniel, Buchert Michael, Newton, Ian P, Heath, Joan, Maree C Faux, Näthke, IS, Burke, Z.D., Heath, J., Maree C. Faux, Faux, Maree C., Winbanks, Catherine E., Heath, J K, Faux, M.C., Abud, Helen, Catherine E. Winbanks, Faux, MC, Sansom, O., Burke, Zoe, Andrew G. Jarnicki, Steven A. Stacker, Hiromu Suzuki, Zoe D. Burke, Huelsken, Joerg, Heath, J.K., Stacker Steven A., Burke Zoe D., Winbanks, CE, Nathke, Inke, Clarke, A.   +150 more
core   +2 more sources

ESR2 Drives Mesenchymal-to-Epithelial Transition in Triple-Negative Breast Cancer and Tumorigenesis In Vivo

Frontiers in Oncology, 2022
Estrogen receptors (ERs) have pivotal roles in the development and progression of triple-negative breast cancer (TNBC). Interactions among cancer cells and tumor microenvironment are orchestrated by the extracellular matrix that is rapidly emerging as ...
Zoi Piperigkou, Zoi Piperigkou, Anastasios Koutsandreas, Marco Franchi, Vasiliki Zolota, Dimitrios Kletsas, Alberto Passi, Nikos K. Karamanos, Nikos K. Karamanos   +8 more
doaj   +1 more source

The role of antimicrobial peptides in skin tumorigenesis

, 2016
Antimicrobial peptides (AMPs), known as “natural antibiotics”, are the first line of defense in humans as effector molecules of the innate immune system of the skin.
Sławomir Majewski, Małgorzata Marcinkiewicz   +1 more
core   +1 more source

P53 mutations in human adrenocortical neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Travis, W., Linehan, M., Karl, M., Chrousos, G. P., Allolio, B., Mastorakis, G., Reincke, Martin   +6 more
core   +1 more source

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

EMBO Molecular Medicine, 2019
Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression.
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas   +23 more
doaj   +1 more source

ODAM Expression Inhibits Human Breast Cancer Tumorigenesis

, 2011
We have posited that Odontogenic Ameloblast Associated Protein (ODAM) serves as a novel prognostic biomarker in breast cancer and now have investigated its potential role in regulating tumor growth and metastasis.
Jonathan S. Wall, James S. Foster, Daniel P. Kestler, Charles T. Bruker, John W. Prenshaw, Alan Solomon, Stephen J. Kennel, Deborah T. Weiss   +7 more
core   +1 more source

Estrogen Signaling in Breast Tumorigenesis

, 2017
The estrogen receptor (ER) is expressed in approximately 70% of sporadic breast cancers and is believed to activate genes driving tumorigenesis and initial cell proliferation.
Chi, David
core   +6 more sources

Target Finder of Transcription Factor (TFoTF): a novel tool to predict transcription factor‐targeted genes in cancer

Molecular Oncology, 2023
Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high‐throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the ...
Fanchen Wang, Xiaolin Xu, Xin Li, Jia Yuan, Xuzhu Gao, Chenglong Wang, Wencai Guan, Guoxiong Xu   +7 more
doaj   +1 more source

Inflammation-Induced Tumorigenesis and Metastasis

, 2021
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent
Hidenori Kasahara, Sana Hibino, Mamiko Sakata-Yanagimoto, Koji Taniguchi, Tetsuro Kawazoe, Shinji Itoh, Takatsugu Ishimoto   +6 more
core   +1 more source