Results 31 to 40 of about 393,410 (301)
Nature Communications, 2016 It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence
Joe Nassour +13 more
doaj +1 more source
Cells, 2019 Background: The role of regulatory T cells (Tregs) is now well established in the progression of hepatocellular carcinoma (HCC) linked to Hepatitis C virus (HCV) infection. However, nothing is known about the potential interplay between Tregs and HCV. In
Laurissa Ouaguia +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Hepatocellular carcinoma (HCC) is a common primary liver cancer with ∼750,000 annual incidence rates globally. PGE2, usually known as a pro-inflammatory cytokine, is over-expressed in various human malignancies including HCC.
Chao Chen +4 more
doaj +1 more source
The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo
International Journal of Cell Biology, 2011 The mammary gland is a unique organ that continually undergoes postnatal developmental changes. In mice, the mammary gland is formed via signals from terminal end buds, which direct ductal growth and elongation.
Karen M. Bussard, Gilbert H. Smith
doaj +1 more source
DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways
Neoplasia: An International Journal for Oncology Research, 2017 DBF4-dependent kinase (DDK) is a two-subunit kinase required for initiating DNA replication at individual origins and is composed of CDC7 kinase and its regulatory subunit DBF4.
Nanda Kumar Sasi +4 more
doaj +1 more source
Evaluation of LRIG1 Expression in Larynx Pathologies
The Turkish Journal of Ear Nose and Throat, 2022 Objective: Studies have been performed on many biomolecules to determine the prognosis of LSCC and predict the course of the disease. However, a molecular marker that can be used clinically has not yet been found.
Yavuz Gündoğdu +6 more
doaj +1 more source
Inflammasomes and intestinal tumorigenesis [PDF]
Drug Discovery Today: Disease Mechanisms, 2011 Colorectal cancer is a major health problem in developed countries. Chronic intestinal inflammation predisposes individuals to the development of colorectal cancer. The intracellular NOD-like receptors (NLRs) have emerged as crucial regulators of intestinal inflammation and colorectal tumorigenesis.
Md Hasan, Zaki +2 more
openaire +2 more sources
Epithelial NAIPs protect against colonic tumorigenesis. [PDF]
, 2015 NLR family apoptosis inhibitory proteins (NAIPs) belong to both the Nod-like receptor (NLR) and the inhibitor of apoptosis (IAP) families. NAIPs are known to form an inflammasome with NLRC4, but other in vivo functions remain unexplored.
Velin, D. +27 more
core +2 more sources
Acetyl-CoA Carboxylases and Diseases
Frontiers in Oncology, 2022 Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs.
Yu Wang +7 more
doaj +1 more source
BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity
EMBO Molecular Medicine, 2017 Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly ...
Eliana MC Tacconi +20 more
doaj +1 more source