Results 31 to 40 of about 320,341 (266)

Acetyl-CoA Carboxylases and Diseases

Frontiers in Oncology, 2022
Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs.
Yu Wang, Weixing Yu, Sha Li, Dingyuan Guo, Jie He, Jie He, Yugang Wang, Yugang Wang   +7 more
doaj   +1 more source

Phosphate toxicity and tumorigenesis [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2018
In this article, we briefly summarized evidence that cellular phosphate burden from phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells express more phosphate cotransporters and store more inorganic phosphate than normal cells, and dysregulated phosphate homeostasis is associated with the genesis of various human ...
Brown, Ronald B., Razzaque, Mohammed S.
openaire   +3 more sources

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

EMBO Molecular Medicine, 2017
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly ...
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas   +20 more
doaj   +1 more source

Mitophagy in tumorigenesis and metastasis

Cellular and Molecular Life Sciences, 2021
Cells use mitophagy to remove dysfunctional or excess mitochondria, frequently in response to imposed stresses, such as hypoxia and nutrient deprivation. Mitochondrial cargo receptors (MCR) induced by these stresses target mitochondria to autophagosomes through interaction with members of the LC3/GABARAP family. There are a growing number of these MCRs,
Logan P, Poole, Kay F, Macleod
openaire   +3 more sources

Adducin in tumorigenesis and metastasis [PDF]

Oncotarget, 2017
Adducin is a membrane-skeletal protein localized at spectrin-actin junctions, involving in the formation of the network of cytoskeleton, cellular signal transduction, ionic transportation, cell motility and cell proliferation. While previous researches focused mainly on the relationship between adducin and hypertension, there are few studies focusing ...
Luo, Cong, Shen, Jiayu
openaire   +2 more sources

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

EMBO Molecular Medicine, 2019
Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression.
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas   +23 more
doaj   +1 more source

The roles of the tumor suppressor parafibromin in cancer

Frontiers in Cell and Developmental Biology, 2022
In this review, we discuss parafibromin protein, which is encoded by CDC73. A mutation in this gene causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disease.
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
doaj   +1 more source

Contributions of Rad9 to tumorigenesis [PDF]

Journal of Cellular Biochemistry, 2012
AbstractRad9 plays a crucial role in maintaining genomic stability by regulating cell cycle checkpoints, DNA repair, telomere stability, and apoptosis. Rad9 controls these processes mainly as part of the heterotrimeric 9‐1‐1 (Rad9‐Hus1‐Rad1) complex.
Constantinos G, Broustas, Howard B, Lieberman   +1 more
openaire   +2 more sources

RAB42 Promotes Glioma Pathogenesis via the VEGF Signaling Pathway

Frontiers in Oncology, 2021
Angiogenesis plays an important role in tumor initiation and progression of glioma. Seeking for biomarkers associated with angiogenesis is important in enhancing our understanding of glioma biologically and identifying its new drug targets.
Baoling Liu, Quanping Su, Bolian Xiao, Guodong Zheng, Lizhong Zhang, Jiawei Yin, Lijuan Wang, Lijuan Wang, Fengyuan Che, Fengyuan Che, Xueyuan Heng   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source