Results 11 to 20 of about 396,195 (253)
Denervation suppresses gastric tumorigenesis. [PDF]
, 2014 The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis.
Zhao, Chun-Mei;Hayakawa, Yoku;Kodama, Yosuke;Muthupalani, Sureshkumar;Westphalen, Christoph B;Andersen, Gøran T;Flatberg, Arnar;Johannessen, Helene;Friedman, Richard A;Renz, Bernhard W;Sandvik, Arne K;Beisvag, Vidar;Tomita, Hiroyuki;Hara, Akira;Quante, Michael;Li, Zhishan;Gershon, Michael D;Kaneko, Kazuhiro;Fox, James G;Wang, Timothy C;Chen, Duan
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DIS3L2: Unveiling a New Player in Tumorigenesis, with a Key Role in Colorectal Cancer [PDF]
, 2023 DIS3L2 is a 3’-5’ exoribonuclease that recognizes and degrades uridylated transcripts in an exosome-independent manner and participates in several RNA degradation pathways, such as the nonsense-mediated mRNA decay, or the surveillance of aberrant ...
García-Moreno, Juan F. +2 more
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ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
Breast Cancer Research, 2018 Background The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer.
Mandy Dumortier +8 more
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Frontiers in Oncology, 2023 IntroductionProprotein convertase subtilisin/kexin-9 (PCSK9) has been primarily studied in the cardiovascular field however, its role in cancer pathophysiology remains incompletely defined.
Chao Sun +7 more
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K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]
, 2011 The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Taketo, M.M. +17 more
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The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse
Scientific Reports, 2018 The transcription factor C/EBPβ regulates hematopoiesis, bone, liver, fat, and skin homeostasis, and female reproduction. C/EBPβ protein expression from its single transcript occurs by alternative in-frame translation initiation at consecutive start ...
Valérie Bégay +4 more
doaj +1 more source
Cell Reports, 2013 The extracellular matrix molecule tenascin-C (TNC) is a major component of the cancer-specific matrix, and high TNC expression is linked to poor prognosis in several cancers.
Falk Saupe +24 more
doaj +1 more source
, 2020 Typical EC related tumorigenesis- and metastasis-associated PAN-ECM genes were identified. Most of them were collage-related genes and were downregulated in tumorigenesis and upregulated in metastasis of EC.
Vijesh Kumar Yadav (8742048) +5 more
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TREM-1 promotes intestinal tumorigenesis. [PDF]
, 2017 Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune responses. Increasing evidence suggests a role for TREM-1 not only in acute pathogen-induced reactions but also in chronic and non ...
Lukas Mager +19 more
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Optogenetic investigation of BMP target gene expression diversity
eLife, 2020 Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis.
Katherine W Rogers +3 more
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