Results 11 to 20 of about 393,410 (301)
Autophagy and tumorigenesis [PDF]
The FEBS Journal, 2021 Autophagy is a catabolic process that captures cellular waste and degrades them in the lysosome. The main functions of autophagy are quality control of cytosolic proteins and organelles, and intracellular recycling of nutrients in order to maintain cellular homeostasis.
Michael Rangel +4 more
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Autophagy and tumorigenesis [PDF]
FEBS Letters, 2009 Autophagy, or cellular self‐digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Nonetheless, genetic evidence supports that autophagy functions as a tumor suppressor mechanism.
Chen, Nan, Debnath, Jayanta
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Autophagy and Tumorigenesis [PDF]
Seminars in Immunopathology, 2010 Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors.
Roy, Srirupa, Debnath, Jayanta
openaire +4 more sources
Aneuploidy and tumorigenesis [PDF]
Seminars in Cell & Developmental Biology, 2011 Aneuploidy is a prominent phenotype of cancer. It refers to deviations from the normal number of chromosomes in a cell, as a result of whole-chromosome loss or gain. In most cases, aneuploidy is caused by mitotic errors due to defects in the mechanisms that have evolved to ensure faithful chromosome segregation, such as the spindle assembly checkpoint (
Xiao, Fang, Pumin, Zhang
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Denervation suppresses gastric tumorigenesis. [PDF]
, 2014 The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis.
Zhao, Chun-Mei;Hayakawa, Yoku;Kodama, Yosuke;Muthupalani, Sureshkumar;Westphalen, Christoph B;Andersen, Gøran T;Flatberg, Arnar;Johannessen, Helene;Friedman, Richard A;Renz, Bernhard W;Sandvik, Arne K;Beisvag, Vidar;Tomita, Hiroyuki;Hara, Akira;Quante, Michael;Li, Zhishan;Gershon, Michael D;Kaneko, Kazuhiro;Fox, James G;Wang, Timothy C;Chen, Duan
core +2 more sources
DIS3L2: Unveiling a New Player in Tumorigenesis, with a Key Role in Colorectal Cancer [PDF]
, 2023 DIS3L2 is a 3’-5’ exoribonuclease that recognizes and degrades uridylated transcripts in an exosome-independent manner and participates in several RNA degradation pathways, such as the nonsense-mediated mRNA decay, or the surveillance of aberrant ...
García-Moreno, Juan F. +2 more
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ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis
Breast Cancer Research, 2018 Background The ETS transcription factor ETV4 is involved in the main steps of organogenesis and is also a significant mediator of tumorigenesis and metastasis, such as in breast cancer.
Mandy Dumortier +8 more
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CD147 Promotes Tumorigenesis via Exosome-Mediated Signaling in Rhabdomyosarcoma
Cells, 2022 Rhabdomyosarcoma (RMS) is an aggressive childhood soft-tissue tumor, with propensity for local invasion and distant metastasis. Exosomes are secreted vesicles that mediate paracrine signaling by delivering functional proteins and miRNA to recipient cells.
Assil Fahs +11 more
doaj +1 more source
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]
, 2011 The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Taketo, M.M. +17 more
core +1 more source
The pathophyiological role of aminoacyl-tRNA synthetases in digestive system diseases
Frontiers in Physiology, 2022 Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate transfer RNAs and are indispensable enzymes for protein biosynthesis in all the cells.
Wugelanmu Wusiman +3 more
doaj +1 more source