Results 21 to 30 of about 38,905 (162)
Targeting the Hippo Pathway for Cardiac Regeneration. [PDF]
Physiology (Bethesda)Ischemic heart disease, which affects more than 200 million people worldwide, is caused by reduced blood flow to the heart and leads to widespread cardiomyocyte death. Due to the limited regenerative potential of cardiomyocytes, the lost tissue is replaced by a fibrotic scar, resulting in reduced cardiac function and progression to heart failure ...
Li RG, Meng F, Martin JF.
europepmc +3 more sources
The Hippo Signaling Pathway Interactome [PDF]
Science, 2013 Dissecting Hippo Interactions The Hippo signaling pathway plays key roles in many processes, from cell proliferation and cell death to regulation of stem cells and cancer cells. Kwon et al. (p.
Kwon, Young +6 more
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USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis
Cell Death and Disease, 2023 Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive pathway for hepatocellular carcinogenesis.
Dongyi Liu +14 more
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The Hippo pathway: regulators and regulations [PDF]
Genes & Development, 2013 Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in both Drosophila and mammals regulates cell number by modulating cell proliferation, cell death, and cell differentiation.
Fa-Xing, Yu, Kun-Liang, Guan
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Okadaic Acid: A Tool to Study the Hippo Pathway
Marine Drugs, 2013 Mammalian Ste20-like kinases 1 and 2 (MST1 and MST2) are activated in NIH3T3 cells exposed to okadaic acid. The Hippo pathway is a newly emerging signaling that functions as a tumor suppressor.
Yutaka Hata +2 more
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Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential
MedComm, 2023 As highly conserved among diverse species, Hippo signaling pathway regulates various biological processes, including development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size.
Liemei Lv, Xiangxiang Zhou
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Frontiers in Immunology, 2023 IntroductionThe Hippo signaling pathway is an evolutionarily conserved signaling cascade that plays a crucial role in regulating cell proliferation, differentiation, and apoptosis.
Fan Mao +21 more
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Mechanisms of Hippo pathway regulation
Genes & Development, 2016 The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years.
Meng, Zhipeng +2 more
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Hippo pathway in lung development [PDF]
Journal of Thoracic Disease, 2017 The mammalian lung is a highly branched organ for oxygen exchange with carbon dioxide in the cardiovascular system. Multiple signaling pathways, including the Wnt, bone morphogenetic protein (Bmp), and fibroblast growth factor (Fgf) pathways, are implicated in regulating lung specification, branching and patterning (1).
Yuyuan, Dai, David, Jablons, Liang, You
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Energy crisis and the Hippo pathway [PDF]
Cell Cycle, 2015 The Hippo pathway is an emerging tumor suppressor pathway that was initially discovered by elegant genetic studies performed in Drosophila. It is now known that this pathway restrains organ size by stimulating programmed cell death and limiting excessive cell growth and division, all properties critical for tissue homeostasis and tumor suppression.
Wenqi, Wang, Xu, Li, Junjie, Chen
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