Results 21 to 30 of about 67,151 (262)

The Hippo Signaling Pathway Interactome [PDF]

Science, 2013
Dissecting Hippo Interactions The Hippo signaling pathway plays key roles in many processes, from cell proliferation and cell death to regulation of stem cells and cancer cells. Kwon et al. (p.
Kwon, Young, Vinayagam, Arunachalam, Sun, Xiaoyun, Dephoure, Noah, Gygi, Steven, Hong, Pengyu, Perrimon, Norbert   +6 more
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Hippo Signaling Pathway in Pancreas Development [PDF]

Frontiers in Cell and Developmental Biology, 2021
The Hippo signaling pathway is a vital regulator of pancreatic development and homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular plasticity. Through loss-of-function research, Hippo signaling has been found to play key roles in maintaining the proper balance between progenitor cell renewal, proliferation, and ...
Yifan Wu, Yifan Wu, Pauline Aegerter, Michael Nipper, Logan Ramjit, Jun Liu, Pei Wang   +6 more
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The HIPPO pathway in gynecological malignancies

American journal of cancer research, 2020
The Hippo pathway has been initially discovered by screening genes that regulate organ size in Drosophila. Recent studies have highlighted the role of the Hippo pathway in controlling organ size, tissue homeostasis and regeneration, and signaling dysregulation, especially the overactivation of the transcriptional coactivator YAP/TAZ, which leads to ...
Dong, J., He, J., Meyer, T., Wang, D., Xu, T.   +4 more
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Hippo pathway in lung development [PDF]

Journal of Thoracic Disease, 2017
The mammalian lung is a highly branched organ for oxygen exchange with carbon dioxide in the cardiovascular system. Multiple signaling pathways, including the Wnt, bone morphogenetic protein (Bmp), and fibroblast growth factor (Fgf) pathways, are implicated in regulating lung specification, branching and patterning (1).
Yuyuan, Dai, David, Jablons, Liang, You
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The Hippo pathway mediates Semaphorin signaling [PDF]

Science Advances, 2022
Semaphorins were originally identified as axonal guidance molecules, but they also control processes such as vascular development and tumorigenesis. The downstream signaling cascades of Semaphorins in these biological processes remain unclear.
Zhipeng Meng, Fu-Long Li, Cao Fang, Benjamin Yeoman, Yunjiang Qiu, Ying Wang, Xiaomin Cai, Kimberly C. Lin, Di Yang, Min Luo, Vivian Fu, Xiaoxiao Ma, Yarui Diao, Filippo G. Giancotti, Bing Ren, Adam J. Engler, Kun-Liang Guan   +16 more
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The critical role of the Hippo signaling pathway in kidney diseases

Frontiers in Pharmacology, 2022
The Hippo signaling pathway is involved in cell growth, proliferation, and apoptosis, and it plays a key role in regulating organ size, tissue regeneration, and tumor development.
Yuting Sun, De Jin, Ziwei Zhang, Di Jin, JiaoJiao Xue, LiYun Duan, YuQing Zhang, XiaoMin Kang, FengMei Lian, FengMei Lian   +9 more
doaj   +1 more source

Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.

PLoS Genetics, 2021
The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanogaster eye, the Hippo pathway controls the fate choice between one of two subtypes that express either the blue light ...
Jonathan M Pojer, Abdul Jabbar Saiful Hilmi, Shu Kondo, Kieran F Harvey   +3 more
doaj   +1 more source

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. [PDF]

, 2015
The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ.
Flores, Fabian, Guan, Kun-Liang, Halder, Georg, Hansen, Carsten G, Hong, Audrey W, Lu, Shicong, Lu, Wenqi, Meng, Zhipeng, Mo, Jung-Soon, Moroishi, Toshiro, Mottier-Pavie, Violaine, Park, Hyun Woo, Plouffe, Steven W, Yu, Fa-Xing   +13 more
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Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy

Cells, 2021
Cancer is a global health problem. The delineation of molecular mechanisms pertinent to cancer initiation and development has spurred cancer therapy in the form of precision medicine. The Hippo signalling pathway is a tumour suppressor pathway implicated
Yvonne Xinyi Lim, Hexian Lin, Sock Hong Seah, Yoon Pin Lim   +3 more
doaj   +1 more source

Histone Acetylation-Mediated Regulation of the Hippo Pathway [PDF]

, 2013
The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer treatment.
A Rebbaa, A Salic, Abdelhadi Rebbaa, Ali J. Marian, B Zhao, B Zhao, BL Mirkin, BR Mardin, BS Robinson, C Alarcon, C Zhang, CA Thorne, D Basu, D Lai, Dipanjan Basu, E Miller, E Pazolli, F Chu, F Kanai, F Martin-Belmonte, FA Grusche, FX Yu, G Halder, H Oh, H Oh, HH Cho, HJ Chen, HM Prince, I Lian, J Avruch, J Zhang, JP Lyons, K Harvey, KF Harvey, KF Harvey, L Azzolin, L Zender, L Zhao, LM McCaffrey, M Cordenonsi, M Sudol, MA St John, Miguel Reyes-Múgica, NA Grzeschik, QY Lei, RS Udan, S Wu, SA Mousa, T de Cristofaro, T Xu, W Huang, WM Konsavage Jr, X Varelas, X Varelas, XJ Li, Y Hao, Y Liu, Y Wang, Z Zhou   +58 more
core   +3 more sources