Results 41 to 50 of about 38,905 (162)
Frontiers in Genetics, 2021 The Hippo signaling pathway has been shown to be involved in regulating cellular identity, cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a kinase cascade which determines the nucleo-cytoplasmic localization of YAP in
Manu Unni +6 more
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Hippo Pathway in Mammalian Adaptive Immune System
Cells, 2019 The Hippo pathway was originally identified as an evolutionarily-conserved signaling mechanism that contributes to the control of organ size. It was then rapidly expanded as a key pathway in the regulation of tissue development, regeneration, and cancer ...
Takayoshi Yamauchi, Toshiro Moroishi
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The Hippo pathway in colorectal cancer
Folia Histochemica et Cytobiologica, 2015 Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with modern drugs targeting cellular components such as epithelial growth factor receptor (EGFR).
Piotr M. Wierzbicki, Agnieszka Rybarczyk
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Clinical and Translational MedicineIntroduction Nephronophthisis (NPH) is an autosomal recessive interstitial cystic kidney disease, which is the most common genetic cause of end‐stage renal disease (ESRD) in childhood.
Yichen Yang +9 more
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Hippo signaling pathway and respiratory diseases
Cell Death Discovery, 2022 The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, and regeneration.
Weifeng Tang +7 more
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Functional annotation of the Hippo pathway somatic mutations in human cancers
Nature CommunicationsThe Hippo pathway is commonly altered in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development remains unclear. Here we analyze the Hippo somatic mutations in the human cancer genome
Han Han +19 more
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New Horizons in Cancer Progression and Metastasis: Hippo Signaling Pathway
BiomedicinesThe Hippo pathway is highly evolved to maintain tissue homeostasis in diverse species by regulating cell proliferation, differentiation, and apoptosis.
Murali R. Kuracha +5 more
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The HIPPO pathway in gynecological malignancies.
American journal of cancer research, 2020 The Hippo pathway has been initially discovered by screening genes that regulate organ size in Drosophila. Recent studies have highlighted the role of the Hippo pathway in controlling organ size, tissue homeostasis and regeneration, and signaling dysregulation, especially the overactivation of the transcriptional coactivator YAP/TAZ, which leads to ...
Wang, D. +4 more
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Molecular Mechanism of Hippo–YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration
Frontiers in Physiology, 2020 The Hippo–YAP1/TAZ pathway is a highly conserved central mechanism that controls organ size through the regulation of cell proliferation and other physical attributes of cells.
Xiaoqing Chen +7 more
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Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer
Cancer Cell International, 2021 Drug resistance is always a great obstacle in any endocrine therapy of breast cancer. Although the combination of endocrine therapy and targeted therapy has been shown to significantly improve prognosis, refractory endocrine resistance is still common ...
Jing Chen +6 more
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