Results 41 to 50 of about 38,775 (145)

The Hippo-p53 pathway in megakaryopoiesis

Haematologica, 2016
Megakaryocytes are among the largest and rarest cells in the body, accounting for approximately 0.01% of nucleated cells in the bone marrow. Their differentiation involves a progression from hematopoietic stem cell to the megakaryocyte progenitor and finally to platelets.[1][1] A key step in ...
Praveen K Suraneni, John D. Crispino
openaire   +3 more sources

Identification of Components of the Hippo Pathway in Hydra and Potential Role of YAP in Cell Division and Differentiation

Frontiers in Genetics, 2021
The Hippo signaling pathway has been shown to be involved in regulating cellular identity, cell/tissue size maintenance and mechanotransduction. The Hippo pathway consists of a kinase cascade which determines the nucleo-cytoplasmic localization of YAP in
Manu Unni, Manu Unni, Puli Chandramouli Reddy, Mrinmoy Pal, Irit Sagi, Sanjeev Galande, Sanjeev Galande   +6 more
doaj   +1 more source

Utilizing the Hippo pathway as a therapeutic target for combating endocrine-resistant breast cancer

Cancer Cell International, 2021
Drug resistance is always a great obstacle in any endocrine therapy of breast cancer. Although the combination of endocrine therapy and targeted therapy has been shown to significantly improve prognosis, refractory endocrine resistance is still common ...
Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang, Alexander Tobias Teichmann   +6 more
doaj   +1 more source

Functional annotation of the Hippo pathway somatic mutations in human cancers

Nature Communications
The Hippo pathway is commonly altered in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development remains unclear. Here we analyze the Hippo somatic mutations in the human cancer genome
Han Han, Zhen Huang, Congsheng Xu, Gayoung Seo, Jeongmin An, Bing Yang, Yuhan Liu, Tian Lan, Jiachen Yan, Shanshan Ren, Yue Xu, Di Xiao, Jonathan K. Yan, Claire Ahn, Dmitry A. Fishman, Zhipeng Meng, Kun-Liang Guan, Ruxi Qi, Ray Luo, Wenqi Wang   +19 more
doaj   +1 more source

Hippo signaling pathway and respiratory diseases

Cell Death Discovery, 2022
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ size, tissue development, and regeneration.
Weifeng Tang, Min Li, Xiaoting Yangzhong, Xifeng Zhang, Anju Zu, Yunjiao Hou, Lin Li, Shibo Sun   +7 more
doaj   +1 more source

New Horizons in Cancer Progression and Metastasis: Hippo Signaling Pathway

Biomedicines
The Hippo pathway is highly evolved to maintain tissue homeostasis in diverse species by regulating cell proliferation, differentiation, and apoptosis.
Murali R. Kuracha, Uppala Radhakrishna, Sreenaga V. Kuracha, Navyasri Vegi, Jhyama Lhamo Gurung, Benita L. McVicker   +5 more
doaj   +1 more source

The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth

Biology Open, 2013
Summary The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer.
Wei Zhang, Stephen M. Cohen
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The Hippo pathway in colorectal cancer

Folia Histochemica et Cytobiologica, 2015
Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with modern drugs targeting cellular components such as epithelial growth factor receptor (EGFR).
Piotr M, Wierzbicki, Agnieszka, Rybarczyk   +1 more
openaire   +3 more sources

Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1KO mice

Clinical and Translational Medicine
Introduction Nephronophthisis (NPH) is an autosomal recessive interstitial cystic kidney disease, which is the most common genetic cause of end‐stage renal disease (ESRD) in childhood.
Yichen Yang, Zhihe Xue, Jiayong Lai, Jinglan Zhang, Changmiao Pang, Jinglin Zhong, Zhanpeng Kuang, Baojuan Zou, Yaqing Liu, Liangzhong Sun   +9 more
doaj   +1 more source

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.

PLoS Genetics, 2016
Hippo signaling acts as a master regulatory pathway controlling growth, proliferation, and apoptosis and also ensures that variations in proliferation do not alter organ size.
Maryam Jahanshahi, Kuangfu Hsiao, Andreas Jenny, Cathie M Pfleger   +3 more
doaj   +1 more source