Results 41 to 50 of about 67,151 (262)
The Hippo Pathway: Immunity and Cancer [PDF]
Cancers, 2018 Since its discovery, the Hippo pathway has emerged as a central signaling network in mammalian cells. Canonical signaling through the Hippo pathway core components (MST1/2, LATS1/2, YAP and TAZ) is important for development and tissue homeostasis while aberrant signaling through the Hippo pathway has been implicated in multiple pathologies, including ...
Zaid Taha +2 more
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The role of non-canonical Hippo pathway in regulating immune homeostasis
European Journal of Medical Research, 2023 The Hippo pathway is a crucial signaling pathway that is highly conserved throughout evolution for the regulation of organ size and maintenance of tissue homeostasis.
Dagang Tang, Huan Xu, Xing Du
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Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View
Frontiers in Cell and Developmental Biology, 2021 Initially identified in Drosophila, the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death ...
Yong Suk Cho, Jin Jiang, Jin Jiang
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SerpinB3 and Yap Interplay Increases Myc Oncogenic Activity [PDF]
, 2015 SerpinB3 has been recently described as an early marker of liver carcinogenesis, but the potential mechanistic role of this serpin in tumor development is still poorly understood.
Biasiolo, Alessandra +16 more
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Clinical and biological implications of Hippo pathway dysregulation in sarcomas
Forum of Clinical Oncology, 2019 Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios +4 more
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The Role of RASSF5 on Cell Growth and Hippo Signaling in Rhabdomyosarcoma [PDF]
, 2020 Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood. Dysregulation of the Hippo pathway, a signaling cascade that regulates many biological processes, is associated with many human cancers.
Garver, Megan +2 more
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Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]
, 2018 Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
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Systematic analysis of the Hippo pathway organization and oncogenic alteration in evolution. [PDF]
, 2020 The Hippo pathway is a central regulator of organ size and a key tumor suppressor via coordinating cell proliferation and death. Initially discovered in Drosophila, the Hippo pathway has been implicated as an evolutionarily conserved pathway in mammals ...
Chen, Yuxuan +7 more
core
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
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Hippo Pathway Key to Ploidy Checkpoint [PDF]
Cell, 2014 Tetraploid cells generated by abnormal cell division are often arrested during the cell cycle or cleared by apoptosis. Evasion of these defense mechanisms leads to genomic instability and tumorigenesis. In this issue, Ganem et al. report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of tetraploidy-induced
Zhao, Bin, Guan, Kun-Liang
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