Results 51 to 60 of about 38,775 (145)

Molecular Mechanism of Hippo–YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration

Frontiers in Physiology, 2020
The Hippo–YAP1/TAZ pathway is a highly conserved central mechanism that controls organ size through the regulation of cell proliferation and other physical attributes of cells.
Xiaoqing Chen, Xiaoqing Chen, Yilang Li, Yilang Li, Jiandong Luo, Jiandong Luo, Ning Hou, Ning Hou   +7 more
doaj   +1 more source

Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside

Biomedicines, 2022
The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression.
Xiaoli Liu, Yifei Wang, Bonan Chen, Wai Nok Chan, Chun Wai Mui, Alvin H.K. Cheung, Jinglin Zhang, Kit Yee Wong, Jun Yu, Wei Kang, Ka Fai To   +10 more
doaj   +1 more source

The HIPPO pathway in gynecological malignancies.

American journal of cancer research, 2020
The Hippo pathway has been initially discovered by screening genes that regulate organ size in Drosophila. Recent studies have highlighted the role of the Hippo pathway in controlling organ size, tissue homeostasis and regeneration, and signaling dysregulation, especially the overactivation of the transcriptional coactivator YAP/TAZ, which leads to ...
Wang, D., He, J., Dong, J., Meyer, T., Xu, T.   +4 more
openaire   +2 more sources

Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

Nature Communications
The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully ...
Yinan Yang, Huijing Zhou, Xiawei Huang, Chengfang Wu, Kewei Zheng, Jingrong Deng, Yonggang Zheng, Jiahui Wang, Xiaofeng Chi, Xianjue Ma, Huimin Pan, Rui Shen, Duojia Pan, Bo Liu   +13 more
doaj   +1 more source

The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’ [PDF]

Cell Death & Differentiation, 2011
The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’
H, McNeill, M, Sudol, G, Halder, S, Strano, G, Blandino, Y, Shaul   +5 more
openaire   +2 more sources

The role of Hippo pathway in ovarian development

Frontiers in Physiology, 2023
The follicle is the functional unit of the ovary, whereby ovarian development is largely dependent on the development of the follicles themselves. The activation, growth, and progression of follicles are modulated by a diverse range of factors, including reproductive endocrine system and multiple signaling pathways.
Mengdi Zhu, Menghao Xu, Jinmin Zhang, Cuihong Zheng   +3 more
openaire   +3 more sources

The Hippo signaling pathway in development and regeneration

Cell Reports
Summary: The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics
Zhenxing Zhong, Zhihan Jiao, Fa-Xing Yu
doaj   +1 more source

Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders

Stem Cell Research & Therapy
Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes-associated protein 1 (YAP)/ WW domain-containing transcription regulator 1 (
Juanjuan Han, Jiale Zhang, Xiaoyi Zhang, Wenxin Luo, Lifei Liu, Yuqing Zhu, Qingfeng Liu, Xin-an Zhang   +7 more
doaj   +1 more source

DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. [PDF]

PLoS ONE, 2017
The YAP and TAZ transcriptional coactivators promote oncogenic transformation. Elevated YAP/TAZ activity has been documented in human tumors. YAP and TAZ are negatively regulated by the Hippo tumor suppressor pathway.
Hung Thanh Nguyen, Jan-Michael Kugler, Stephen M Cohen   +2 more
doaj   +1 more source

RAP2 mediates mechanoresponses of the Hippo pathway [PDF]

Nature, 2018
Mammalian cells are surrounded by neighbouring cells and extracellular matrix (ECM), which provide cells with structural support and mechanical cues that influence diverse biological processes1. The Hippo pathway effectors YAP (also known as YAP1) and TAZ (also known as WWTR1) are regulated by mechanical cues and mediate cellular responses to ECM ...
Meng, Zhipeng, Qiu, Yunjiang, Lin, Kimberly C, Kumar, Aditya, Placone, Jesse K, Fang, Cao, Wang, Kuei-Chun, Lu, Shicong, Pan, Margaret, Hong, Audrey W, Moroishi, Toshiro, Luo, Min, Plouffe, Steven W, Diao, Yarui, Ye, Zhen, Park, Hyun Woo, Wang, Xiaoqiong, Yu, Fa-Xing, Chien, Shu, Wang, Cun-Yu, Ren, Bing, Engler, Adam J, Guan, Kun-Liang   +22 more
openaire   +4 more sources