Results 51 to 60 of about 38,905 (162)

Targeting the Hippo Pathway in Gastric Cancer and Other Malignancies in the Digestive System: From Bench to Bedside

Biomedicines, 2022
The Hippo pathway is an evolutionally conserved signaling cascade that controls organ size and tissue regeneration under physiological conditions, and its aberrations have been well studied to promote tumor initiation and progression.
Xiaoli Liu, Yifei Wang, Bonan Chen, Wai Nok Chan, Chun Wai Mui, Alvin H.K. Cheung, Jinglin Zhang, Kit Yee Wong, Jun Yu, Wei Kang, Ka Fai To   +10 more
doaj   +1 more source

Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

Nature Communications
The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully ...
Yinan Yang, Huijing Zhou, Xiawei Huang, Chengfang Wu, Kewei Zheng, Jingrong Deng, Yonggang Zheng, Jiahui Wang, Xiaofeng Chi, Xianjue Ma, Huimin Pan, Rui Shen, Duojia Pan, Bo Liu   +13 more
doaj   +1 more source

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.

PLoS Genetics, 2016
Hippo signaling acts as a master regulatory pathway controlling growth, proliferation, and apoptosis and also ensures that variations in proliferation do not alter organ size.
Maryam Jahanshahi, Kuangfu Hsiao, Andreas Jenny, Cathie M Pfleger   +3 more
doaj   +1 more source

The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth

Biology Open, 2013
Summary The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer.
Wei Zhang, Stephen M. Cohen
doaj   +1 more source

The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’ [PDF]

Cell Death & Differentiation, 2011
The Hippo tumor suppressor pathway: a report on ‘the second workshop on the Hippo tumor suppressor pathway’
H, McNeill, M, Sudol, G, Halder, S, Strano, G, Blandino, Y, Shaul   +5 more
openaire   +2 more sources

DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins. [PDF]

PLoS ONE, 2017
The YAP and TAZ transcriptional coactivators promote oncogenic transformation. Elevated YAP/TAZ activity has been documented in human tumors. YAP and TAZ are negatively regulated by the Hippo tumor suppressor pathway.
Hung Thanh Nguyen, Jan-Michael Kugler, Stephen M Cohen   +2 more
doaj   +1 more source

RAP2 mediates mechanoresponses of the Hippo pathway [PDF]

Nature, 2018
Mammalian cells are surrounded by neighbouring cells and extracellular matrix (ECM), which provide cells with structural support and mechanical cues that influence diverse biological processes1. The Hippo pathway effectors YAP (also known as YAP1) and TAZ (also known as WWTR1) are regulated by mechanical cues and mediate cellular responses to ECM ...
Meng, Zhipeng, Qiu, Yunjiang, Lin, Kimberly C, Kumar, Aditya, Placone, Jesse K, Fang, Cao, Wang, Kuei-Chun, Lu, Shicong, Pan, Margaret, Hong, Audrey W, Moroishi, Toshiro, Luo, Min, Plouffe, Steven W, Diao, Yarui, Ye, Zhen, Park, Hyun Woo, Wang, Xiaoqiong, Yu, Fa-Xing, Chien, Shu, Wang, Cun-Yu, Ren, Bing, Engler, Adam J, Guan, Kun-Liang   +22 more
openaire   +4 more sources

Emerging role and function of Hippo-YAP/TAZ signaling pathway in musculoskeletal disorders

Stem Cell Research & Therapy
Hippo pathway is an evolutionarily conservative key pathway that regulates organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. Yes-associated protein 1 (YAP)/ WW domain-containing transcription regulator 1 (
Juanjuan Han, Jiale Zhang, Xiaoyi Zhang, Wenxin Luo, Lifei Liu, Yuqing Zhu, Qingfeng Liu, Xin-an Zhang   +7 more
doaj   +1 more source

The Hippo signaling pathway in development and regeneration

Cell Reports
Summary: The Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics
Zhenxing Zhong, Zhihan Jiao, Fa-Xing Yu
doaj   +1 more source

How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases

Journal of Immunology Research, 2018
Cardiovascular disease remains the leading cause of death around the globe. Cardiac deterioration is associated with irreversible cardiomyocyte loss. Understanding how the cardiovascular system develops and the pathological processes of cardiac disease ...
Wenyi Zhou, Mingyi Zhao
doaj   +1 more source