Results 71 to 80 of about 38,775 (145)

Hippo Signaling in Cancer: Lessons From Drosophila Models

Frontiers in Cell and Developmental Biology, 2019
Hippo pathway was initially identified through genetic screens for genes regulating organ size in fruitflies. Recent studies have highlighted the role of Hippo signaling as a key regulator of homeostasis, and in tumorigenesis.
Kirti Snigdha, Karishma Sanjay Gangwani, Gauri Vijay Lapalikar, Amit Singh, Amit Singh, Amit Singh, Amit Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh, Madhuri Kango-Singh   +10 more
doaj   +1 more source

The history and regulatory mechanism of the Hippo pathway

BMB Reports, 2018
How the organ size is adjusted to the proper size during development and how organs know that they reach the original size during regeneration remain long-standing questions. Based on studies using multiple model organisms and approaches for over 20 years, a consensus has been established that the Hippo pathway plays crucial roles in controlling organ ...
Kim, Wantae, Jho, Eek-hoon
openaire   +3 more sources

The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary.

PLoS Genetics, 2015
The Hippo pathway regulates organ size, stem cell proliferation and tumorigenesis in adult organs. Whether the Hippo pathway influences establishment of stem cell niche size to accommodate changes in organ size, however, has received little attention ...
Didem P Sarikaya, Cassandra G Extavour
doaj   +1 more source

The Hippo tumor suppressor pathway triggers non-cell autonomous tumorigenesis in Drosophila

EMBO Reports
The Hippo pathway is a tumor suppressor pathway, and most related studies have indicated that its inhibition leads to tumorigenesis. However, recent studies have suggested that the activated Hippo pathway can promote tumorigenesis in certain contexts ...
Daichi Honda, Misako Okumura, Ayano Oi, Chisako Sakuma, Fumiaki Obata, Toshinori Ando, Masayuki Miura, Takahiro Chihara   +7 more
doaj   +1 more source

Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer

Journal of Translational Medicine
Background First identified in Drosophila melanogaster, the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. Hippo signaling components include kinases whose activity regulates YAP and TAZ final
Giulia Schiavoni, Beatrice Messina, Stefano Scalera, Lorenzo Memeo, Cristina Colarossi, Marzia Mare, Giovanni Blandino, Gennaro Ciliberto, Giulia Bon, Marcello Maugeri-Saccà   +9 more
doaj   +1 more source

SnapShot: The Hippo Signaling Pathway

Cell, 2011
Badouel, Caroline, McNeill, Helen
openaire   +2 more sources

Research on the Hippo Pathway in Cancer. [PDF]

Cells
Dang F, Dai S, Zhao T, Zhang R, Chen L, Zhao Y.   +5 more
europepmc   +1 more source

Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies. [PDF]

J Hypertens
Zheng D, Guo Y.
europepmc   +1 more source

Luteinizing hormone activates the Hippo pathway to promote progesterone synthesis in bovine luteal cells. [PDF]

Cell Commun Signal
Tamanaeifar F, Owolabi BA, Monaco CF, Moses RM, Castillo AC, Cupp AS, Davis JS, Plewes MR.   +7 more
europepmc   +1 more source

Hippo pathway activation drives fibrogenic remodelling in influenza A virus-infected lung fibroblasts. [PDF]

ERJ Open Res
Reisser Y, Winkler E, Hoffmann J, Kumar ND, Häder A, Lang SM, Löffler B, Deinhardt-Emmer S.   +7 more
europepmc   +1 more source