Results 1 to 10 of about 104,111 (207)
Interplay between YAP/TAZ and Metabolism [PDF]
Cell Metabolism, 2018 Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are two homologous transcriptional coactivators that promote cell proliferation, stem cell maintenance, and tissue homeostasis. Under favorable conditions, YAP and TAZ are active to promote cell growth through a transcriptional program mediated by the TEAD family ...
Ja Hyun Koo, Kun-Liang Guan
exaly +3 more sources
Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Ischemic stroke remains a leading cause of morbidity and mortality worldwide, with limited treatment options available. Vascular dysfunction is a key pathomechanism, and brain endothelial cells (bECs) play a critical role in determining stroke
Ria Göttert +12 more
doaj +2 more sources
Hadisteki İlleti Tespit ve Tenkit Prensibi Olarak: 'Filan Râvinin Rivâyetine Benzemiyor' İfadesi
Cumhuriyet İlahiyat Dergisi, 2023 Hadislerin sıhhatinin tespiti için muhaddisler tarafından hadisin sened ve metnini ilgilendiren birtakım şartlar belirlenmiştir. Bu şartların sened ve metne bakan yönleri bulunmaktadır. Bu şartlardan biri de hadisin illetli olmamasıdır. Hadisin sıhhatini
Bahadır Opus
doaj +1 more source
Biology Open, 2021 Intestinal cell lineage differentiation is a tightly regulated mechanism that involves several intracellular signaling pathways affecting the expression of a variety of transcription factors, which ultimately regulate cell specific gene expression ...
Sepideh Fallah, Jean-François Beaulieu
doaj +1 more source
Inhibition of TAZ impairs the migration ability of melanoma cells
Open Life Sciences, 2023 Malignant melanoma (MM) is characterized by rapid growth, frequent metastasis, and high mortality. Targeted therapy for MM is still a research hotspot due to the increasing understanding of the hippo pathway.
Zhang Hao +4 more
doaj +1 more source
Yurak-Samoyeds: Problems of Ethnic Identification
Арктика и Север, 2021 The article is devoted to the poorly studied problem of the origin of the name Yuraki, which the Russians, as well as the Enets and Nganasans, called the group of the Samoed-speaking population that wandered along the northern outskirts of Western ...
Yuriy N. KVASHNIN
doaj +1 more source
Cancer Biology & Medicine, 2021 Objective: Bone metastasis is a clinically important outcome of prostate carcinoma (PC). We focused on the phenotypic and functional characterization of a particularly aggressive phenotype within the androgen-independent bone metastasis-derived PC3 cell ...
Rosaria A. Fontanella +14 more
doaj +1 more source
TAZ Forces Lateral Inhibition [PDF]
Developmental Cell, 2019 New mechanisms by which cells communicate to specify cell fate during animal development are continuously being discovered. In a recently published article in Cell, Xia et al. (2019) identify the transcriptional regulator TAZ as a novel mediator of lateral inhibition in zebrafish oogenesis that directs cell fate through mechanical cues.
Joseph G, Kern, Xaralabos, Varelas
openaire +2 more sources
Polish Journal of Pathology, 2022 There is growing evidence which indicates that the development and the biological features of cancer such as the invasion, metastases and recurrence are related to the presence and behavior of the cancer stem cells (CSC).
Olga Stasikowska-Kanicka +4 more
doaj +1 more source
Mouse tafazzin is required for male germ cell meiosis and spermatogenesis [PDF]
, 2015 Barth syndrome is an X-linked mitochondrial disease, symptoms of which include neutropenia and cardiac myopathy. These symptoms are the most significant clinical consequences of a disease, which is increasingly recognised to have a variable presentation.
Bryson, S. +6 more
core +7 more sources