Results 11 to 20 of about 24,287 (262)
TAZ is required for chondrogenesis and skeletal development [PDF]
Cell Discovery, 2021 Chondrogenesis is a major contributor to skeletal development and maintenance, as well as bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key regulator of osteogenesis and adipogenesis, but how TAZ regulates chondrogenesis and ...
Yang Li +3 more
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TAZ WW Domain-Mediated Regulation of Gluconeogenesis and Tumorigenesis in Hepatocellular Carcinoma through Interaction with the Glucocorticoid Receptor [PDF]
Endocrinology and MetabolismBackground Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality, characterized by poor prognosis due to its high proliferative and invasive potential. Tumor metabolic reprogramming, particularly involving glucose metabolism, is essential
Hongxiang Huang +12 more
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YAP/TAZ in Bone and Cartilage Biology [PDF]
Frontiers in Cell and Developmental Biology, 2022 YAP and TAZ were initially described as the main regulators of organ growth during development and more recently implicated in bone biology. YAP and TAZ are regulated by mechanical and cytoskeletal cues that lead to the control of cell fate in response to the cellular microenvironment.
Mylène Zarka +5 more
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The sweet side of YAP/TAZ [PDF]
Cell Cycle, 2015 The reprogramming of cancer cell metabolism toward aerobic glycolysis, i.e. the Warburg effect, is a hallmark of cancer; the rationale for selecting such energy-inefficient metabolism is the need to increase cellular biomass and sustain the high proliferation rates of cancer cells.1 Metabolic reprogramming is generally considered as a phenotypic ...
Santinon G., Enzo E., Dupont S.
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TAZ Forces Lateral Inhibition [PDF]
Developmental Cell, 2019 New mechanisms by which cells communicate to specify cell fate during animal development are continuously being discovered. In a recently published article in Cell, Xia et al. (2019) identify the transcriptional regulator TAZ as a novel mediator of lateral inhibition in zebrafish oogenesis that directs cell fate through mechanical cues.
Joseph G, Kern, Xaralabos, Varelas
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YAP/TAZ at the Roots of Cancer [PDF]
Cancer Cell, 2016 YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer initiation or growth of most solid tumors. Their activation induces cancer stem cell attributes, proliferation, chemoresistance, and metastasis.
Zanconato, Francesca +2 more
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Frontiers in Pharmacology, 2020 BackgroundWe explored the therapeutic and prognostic effect of YAP/TAZ intensityinHER2-positive breast cancer patients. We also investigated the relationship between YAP/TAZ expression and Trastuzumab-resistance.MethodsWe collected clinicopathological ...
Jia-qi Yuan, Nian-hua Ding, Zhi Xiao
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Protein & Cell, 2016 TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress,
Xin Zhou, Qun-Ying Lei
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AR activates YAP/TAZ differentially in prostate cancer
Life Science Alliance, 2023 We show YAP and TAZ are differentially activated upon androgen stimulation. Through genetic targeting of YAP, we show that YAP drives the ability for anchorage independent growth and find that YAP/TAZ is not essential for AR signalling.
Omar Salem +3 more
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Tafazzin (TAZ) promotes the tumorigenicity of cervical cancer cells and inhibits apoptosis. [PDF]
PLoS ONE, 2017 Tafazzin (TAZ) is often aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms. However, the function of TAZ in cervical cancer cells remains unknown.
Mei Chen, Yuan Zhang, Peng-Sheng Zheng
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