Results 11 to 20 of about 104,199 (294)
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. [PDF]
, 2015 The Hippo pathway plays a central role in tissue homoeostasis, and its dysregulation contributes to tumorigenesis. Core components of the Hippo pathway include a kinase cascade of MST1/2 and LATS1/2 and the transcription co-activators YAP/TAZ.
Flores, Fabian +13 more
core +2 more sources
Cells, 2020 Transcriptional coactivator with a PDZ-binding motif (TAZ) is one of the mammalian orthologs of Drosophila Yorkie, a transcriptional coactivator of the Hippo pathway. TAZ has been suggested to function as a regulator that modulates the expression of cell
Chiharu Miyajima +8 more
doaj +1 more source
The Influence of Gandhi's Economic Thoughts on the Indian Economy
Indialogs: Spanish Journal of India Studies, 2021 Gandhi wanted the Indian economy to center around autonomous village republics rather than work on the back of large-scale industries or consumption expenditure. Gandhi’s principles for formulating his economic thoughts were based on a call to ‘return to
Taz Mazinder Barua
doaj +1 more source
YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes [PDF]
European Cells & Materials, 2020 The roles of cell division control protein 42 homologue (CDC42) and actin polymerisation in regulating the phenotype of superficial-zone chondrocytes (SZCs) have been demonstrated in vitro; however, the signalling pathway(s) downstream have yet to be ...
E Delve +5 more
doaj +1 more source
Defining functional classes of Barth syndrome mutation in humans [PDF]
, 2016 The X-linked disease Barth syndrome (BTHS) is caused by mutations in TAZ; TAZ is the main determinant of the final acyl chain composition of the mitochondrial-specific phospholipid, cardiolipin.
Claypool, Steven M. +12 more
core +2 more sources
Mechanisms of YAP/TAZ transcriptional control [PDF]
Cell Stress, 2021 Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor microenvironment.
Battilana G., Zanconato F., Piccolo S.
openaire +4 more sources
Advanced Science, 2021 The Hippo pathway effector TAZ promotes cellular growth, survival, and stemness through regulating gene transcription. Recent studies suggest that TAZ liquid–liquid phase separation (LLPS) compartmentalizes key cofactors to activate transcription ...
Yiju Wei +10 more
doaj +1 more source
Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells.
Dhall, Deepti +4 more
core +1 more source
Tafazzin (TAZ) promotes the tumorigenicity of cervical cancer cells and inhibits apoptosis. [PDF]
PLoS ONE, 2017 Tafazzin (TAZ) is often aberrantly expressed in some cancers, including rectal cancer and thyroid neoplasms. However, the function of TAZ in cervical cancer cells remains unknown.
Mei Chen, Yuan Zhang, Peng-Sheng Zheng
doaj +1 more source
AR activates YAP/TAZ differentially in prostate cancer
Life Science Alliance, 2023 We show YAP and TAZ are differentially activated upon androgen stimulation. Through genetic targeting of YAP, we show that YAP drives the ability for anchorage independent growth and find that YAP/TAZ is not essential for AR signalling.
Omar Salem +3 more
doaj +1 more source