Results 41 to 50 of about 24,096 (164)

Devilish Effects of Taz in Nonalcoholic Steatohepatitis [PDF]

Cell Metabolism, 2016
Nonalcoholic steatohepatitis leads to cirrhosis and cancer in a rising number of patients with metabolic syndrome. In this issue of Cell Metabolism, Wang et al. (2016) identify the transcriptional co-activator Taz as a driver of inflammation and fibrosis through the induction of Indian hedgehog in hepatocytes, which stimulates fibrogenesis by hepatic ...
Scott L, Friedman, Youngmin A, Lee
openaire   +2 more sources

Verteporfin reverses progestin resistance through YAP/TAZ-PI3K-Akt pathway in endometrial carcinoma

Cell Death Discovery, 2023
Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP and TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway,
Lina Wei, Xiaohong Ma, Yixin Hou, Tianyi Zhao, Rui Sun, Chunping Qiu, Yao Liu, Ziyi Qiu, Zhiming Liu, Jie Jiang   +9 more
doaj   +1 more source

The Hippo Pathway Effector Transcriptional Co-activator With PDZ-Binding Motif Correlates With Clinical Prognosis and Immune Infiltration in Colorectal Cancer

Frontiers in Medicine, 2022
The transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo pathway. It has been identified as an oncogene in certain tumor types; however, the function and role of TAZ in colorectal cancer (CRC) has not been ...
Yutong Wang, Hui Nie, Huiling Li, Zhiming Liao, Xuejie Yang, Xiaoyun He, Jian Ma, Jianhua Zhou, Jianhua Zhou, Chunlin Ou, Chunlin Ou   +10 more
doaj   +1 more source

Incidence and impact on clinical outcome of infections with piperacillin/tazobactam resistant Escherichia coli in ICU: A retrospective study

BMC Infectious Diseases, 2008
Background Escherichia coli infections are frequent in ICU patients. The increased resistance to fluoroquinolones and amoxicillin/clavulanate of this pathogen mandates the prescription of broad-spectrum antibiotics such as piperacillin/tazobactam (PIP ...
Mounier Roman, Chevrel Guillaume, Eveillard Mathieu, Barnaud Guilène, Ricard Jean-Damien, Meybeck Agnès, Dreyfuss Didier   +6 more
doaj   +1 more source

TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cells lines C2C12, and MEFs induced by BMP9

Cell Death Discovery, 2022
Bone morphogenetic protein 9 (BMP9), also named as growth differentiation factor 2 (GDF-2), is the strongest cytokine that promotes osteogenic differentiation in the BMP family, and has broad clinical application value.
Huakun Huang, Qiuping Lu, Caihong Ye, Mengqi Wei, Chunmei Yang, Lulu Zhang, Yanran Huang, Xiaoji Luo, Jinyong Luo   +8 more
doaj   +1 more source

The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ

Cell Death and Disease, 2022
Dysregulated abundance, location and transcriptional output of Hippo signaling effector TAZ have been increasingly linked to human cancers including head neck squamous cell carcinoma (HNSCC). TAZ is subjected to ubiquitination and degradation mediated by
Jin Li, Yibin Dai, Han Ge, Songsong Guo, Wei Zhang, Yanling Wang, Laikui Liu, Jie Cheng, Hongbing Jiang   +8 more
doaj   +1 more source

Thyroid development in zebrafish lacking Taz

Mechanisms of Development, 2015
Taz is a signal-responsive transcriptional coregulator implicated in several biological functions, from chondrogenesis to regulation of organ size. Less well studied, however, is its role in thyroid formation. Here, we explored the in vivo effects on thyroid development of morpholino (MO)-mediated knockdown of wwtr1, the gene encoding zebrafish Taz ...
Pappalardo A., Porreca I., Caputi L., De Felice E., Schulte-Merker S., Zannini M., Sordino P.   +6 more
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The emerging role of YAP/TAZ in mechanotransduction [PDF]

Journal of Thoracic Disease, 2017
Cells sense their physical surroundings through mechanotransduction—that is by translating mechanical forces and deformations into biochemical signals that can ultimately influence gene expression, cell shape and cell fate. Recently, YAP/TAZ—the main transcriptional effectors of the Hippo signalling pathway, a major growth regulatory pathway within ...
Zahra, Mohri, Armando, Del Rio Hernandez, Rob, Krams   +2 more
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The Hippo Coactivator TAZ Exacerbates Cisplatin-Induced Acute Renal Injury

Kidney Diseases
Introduction: Transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo signaling pathway effector, maintains the balance of cell proliferation, differentiation, and death. However, the role of TAZ in tubular cell survival and acute kidney injury
Xian Xue, Xingwen Zhu, Lu Zhou, Xiaoli Sun, Mengru Gu, Yan Liang, Mengzhu Tan, Qing Hou, Sudan Wang, Chunsun Dai   +9 more
doaj   +1 more source

Nuclear Import and Export of YAP and TAZ

Cancers, 2023
Yes-associated Protein (YAP) and its paralog Transcriptional Coactivator with PDZ-binding Motif (TAZ) are major regulators of gene transcription/expression, primarily controlled by the Hippo pathway and the cytoskeleton. Integrating an array of chemical and mechanical signals, they impact growth, differentiation, and regeneration.
Kofler, Michael, Kapus, András
openaire   +2 more sources