Results 41 to 50 of about 104,199 (294)

Rarefied elliptic hypergeometric functions [PDF]

, 2018
Two exact evaluation formulae for multiple rarefied elliptic beta integrals related to the simplest lens space are proved. They generalize evaluations of the type I and II elliptic beta integrals attached to the root system $C_n$. In a special $n=1$ case,
Spiridonov, V.
core   +3 more sources

Research Advances in Targeting the YAP/TAZ Signaling Pathway 
to Improve Cancer Immunotherapy

Chinese Journal of Lung Cancer
Despite the groundbreaking advances in cancer immunotherapy achieved by immune checkpoint inhibitors (ICIs), their efficacy remains limited by the immunosuppressive tumor microenvironment (TME).
Pingxu ZHANG, Yiyi ZHAN
doaj   +1 more source

The political philosophy and ontology of autonomous zones

Интеллект. Инновации. Инвестиции
The article reveals the content of the Temporary Autonomous Zones’ conception (TAZ), proposed by the American anarchist thinker and poet Hakim Bey (real name – Peter Lamborn Wilson, 1945–2022) and rather poorly represented in Russian-language scientific ...
D. B. Polyakov
doaj   +1 more source

The Hippo Pathway Effector Transcriptional Co-activator With PDZ-Binding Motif Correlates With Clinical Prognosis and Immune Infiltration in Colorectal Cancer

Frontiers in Medicine, 2022
The transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo pathway. It has been identified as an oncogene in certain tumor types; however, the function and role of TAZ in colorectal cancer (CRC) has not been ...
Yutong Wang, Hui Nie, Huiling Li, Zhiming Liao, Xuejie Yang, Xiaoyun He, Jian Ma, Jianhua Zhou, Jianhua Zhou, Chunlin Ou, Chunlin Ou   +10 more
doaj   +1 more source

The sweet side of YAP/TAZ [PDF]

Cell Cycle, 2015
The reprogramming of cancer cell metabolism toward aerobic glycolysis, i.e. the Warburg effect, is a hallmark of cancer; the rationale for selecting such energy-inefficient metabolism is the need to increase cellular biomass and sustain the high proliferation rates of cancer cells.1 Metabolic reprogramming is generally considered as a phenotypic ...
Santinon G., Enzo E., Dupont S.
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Verteporfin reverses progestin resistance through YAP/TAZ-PI3K-Akt pathway in endometrial carcinoma

Cell Death Discovery, 2023
Progestin resistance is a problem for patients with endometrial carcinoma (EC) who require conservative treatment with progestin, and its underlying mechanisms remain unclear. YAP and TAZ (YAP/TAZ), downstream transcription coactivators of Hippo pathway,
Lina Wei, Xiaohong Ma, Yixin Hou, Tianyi Zhao, Rui Sun, Chunping Qiu, Yao Liu, Ziyi Qiu, Zhiming Liu, Jie Jiang   +9 more
doaj   +1 more source

Antibiotic residues and antibiotic-resistant bacteria in pig slurry used to fertilize agricultural fields [PDF]

, 2020
Pig manure may contain antibiotic residues, antibiotic-resistant bacteria or pathogens, which may reach the environment upon fertilization. During this study, 69 antibiotic residues belonging to 12 classes were quantified in 89 pig slurry samples.
Colson, Lander, Daeseleire, Els, De Carvalho Ferreira, Helena Cardoso, Decrop, Johan, Dewulf, Jeroen, Herman, Lieve, Heyndrickx, Marc, Meirlaen, Jurgen, Rasschaert, Geertrui, Van Elst, Daan   +9 more
core   +2 more sources

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source