Results 61 to 70 of about 24,096 (164)

YAP/TAZ initiate and maintain Schwann cell myelination

eLife, 2017
Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance.
Matthew Grove, Hyukmin Kim, Maryline Santerre, Alexander J Krupka, Seung Baek Han, Jinbin Zhai, Jennifer Y Cho, Raehee Park, Michele Harris, Seonhee Kim, Bassel E Sawaya, Shin H Kang, Mary F Barbe, Seo-Hee Cho, Michel A Lemay, Young-Jin Son   +15 more
doaj   +1 more source

Hippo-YAP/TAZ signaling in angiogenesis

BMB Reports, 2018
Angiogenesis is a complex, multistep process involving dynamic changes in endothelial cell (EC) shapes and behaviors, especially in specialized cell types such as tip cells (with active filopodial extensions), stalk cells (with less motility) and phalanx cells (with stable junction connections).
Park, Jeong Ae, Kwon, Young-Guen
openaire   +3 more sources

TAZ deficiency exacerbates psoriatic pathogenesis by increasing the histamine-releasing factor

Cell & Bioscience
Background Transcriptional coactivator with PDZ-biding motif (TAZ) is widely expressed in most tissues and interacts with several transcription factors to regulate cell proliferation, differentiation, and death, thereby influencing organ development and ...
Jiseo Song, Hyo Kyeong Kim, Hyunsoo Cho, Suh Jin Yoon, Jihae Lim, Kyunglim Lee, Eun Sook Hwang   +6 more
doaj   +1 more source

TAZ enhances the activity of the AKT signaling pathway to promote adipogenesis of gADSCs

Stem Cell Research & Therapy
Adipose-derived mesenchymal stem cells (ADSCs) possess the capacity for multidirectional differentiation, including differentiation into adipocytes. However, the molecular mechanisms that control adipogenesis are not yet fully understood.Transcriptional ...
Mei Zhou, Hongyan Zhang, Xiong Miao, Ying Zhao, Long Zhu, Jie Liu, Dongjun Liu   +6 more
doaj   +1 more source

YAP1/TAZ Mediates Rumen Epithelial Cell Proliferation but Not Short-Chain Fatty Acid Metabolism In Vitro

Animals
Promoting rumen development is closely related to the health and efficient growth of ruminants. The transcriptional co-activators Yes1-associated protein (YAP1) and WW domain-containing transcription regulator protein 1 (TAZ) are key regulators of the ...
Bin Yang, Zebang Xu, Hongwei Chen, Tingting Ma, Yiming Zhao, Mengxin Pang, Jiakun Wang   +6 more
doaj   +1 more source

TAZ-Auftritt: Fazit

, 2009
Meike Laaff hat eine kurze Zusammenfassung des Panels gestern auf dem TAZ-Kongress geschrieben, in dem ich mit Christian Sprang vom Börsenverein, Helge Malchow von KiWi und Andreas Bogk vom Chaos Computer Club über E-Books, Urheberrecht, Pirate Bay diskutiert habe.
openaire   +1 more source

Loss of Endothelial YAP/TAZ Reduces the Size of Chronic Stroke Lesions and Alters the Endothelial Environment

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Ischemic stroke remains a leading cause of morbidity and mortality worldwide, with limited treatment options available. Vascular dysfunction is a key pathomechanism, and brain endothelial cells (bECs) play a critical role in determining stroke
Ria Göttert, Majed Kikhia, Marie‐Louise Herzog, Wen Pan, Alexandra Klaus‐Bergmann, January Weiner, Dieter Beule, Samuel Knauss, Golo Kronenberg, Michael Potente, Holger Gerhardt, Matthias Endres, Karen Gertz   +12 more
doaj   +1 more source

TAZ/NRF2 positive feedback loop contributes to proliferation in bladder cancer through antagonistic ferroptosis

Cell Death Discovery
Bladder cancer (BLCA) is a prevalent malignancy characterized by high recurrence and metastasis rates. Emerging evidence suggests that the NRF2-GPX4 axis is closely associated with ferroptosis. The transcriptional coactivator with PDZ-binding motif (TAZ)
Zhen Song, Shikai Gui, Xuepeng Rao, Gan Zhang, Yu Cheng, Tao Zeng   +5 more
doaj   +1 more source

AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis

Scientific Reports
Hepatic fibrosis is driven by the activation of hepatic stellate cells (HSCs). The Hippo pathway and its effectors, YAP and TAZ, are key regulators of HSC activation and fibrosis.
Mahbubul H. Shihan, Sachin Sharma, Carson Cable, Vijaya Prathigudupu, Alina Chen, Aras N. Mattis, Jennifer Y. Chen   +6 more
doaj   +1 more source

A non-canonical repressor function of JUN restrains YAP activity and liver cancer growth

The EMBO Journal
Yes-associated protein (YAP) and its homolog, transcriptional coactivator with PDZ-binding motif (TAZ), are the main transcriptional downstream effectors of the Hippo pathway.
Yuliya Kurlishchuk, Anita Cindric Vranesic, Marco Jessen, Alexandra Kipping, Christin Ritter, KyungMok Kim, Paul Cramer, Björn von Eyss   +7 more
doaj   +1 more source