Results 71 to 80 of about 104,199 (294)

A positive feedback loop between TAZ and miR-942-3p modulates proliferation, angiogenesis, epithelial-mesenchymal transition process, glycometabolism and ROS homeostasis in human bladder cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Transcriptional coactivator with PDZ-binding motif (TAZ) has been reported to be involved in tumor progression, angiogenesis, epithelial-mesenchymal transition (EMT), glycometabolic modulation and reactive oxygen species (ROS) buildup. Herein,
Feifan Wang, Mengjing Fan, Xuejian Zhou, Yanlan Yu, Yueshu Cai, Hongshen Wu, Yan Zhang, Jiaxin Liu, Shihan Huang, Ning He, Zhenghui Hu, Guoqing Ding, Xiaodong Jin   +12 more
doaj   +1 more source

Driving to Opportunity: Understanding the Links among Transportation Access, Residential Outcomes, and Economic Opportunity for Housing Voucher Recipients [PDF]

, 2014
In the 1990s and early 2000s, the Department of Housing and Urban Development sponsored two major experiments to test whether housing choice vouchers propelled low-income households into greater economic security, the Moving to Opportunity for Fair ...
Arthur Taz George, Christopher Hayes, Rolf Pendall, Zach McDade   +3 more
core  

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Hypoxia promotes proliferation of alveolar epithelial cells by regulating chromatin H2A.Z deposition through TAZ-H2A.Z axis

陆军军医大学学报
Objective‍　‍To explore the role and underlying mechanism of the transcriptional coactivator with PDZ-binding motif (TAZ) and a histone variant of acute histone H2A (H2A.Z) in the repair of hypoxia-induced lung injury.
LIU Paiyu , LIU Paiyu , Department of Psychiatry and Psychology， No. 991 Hospital of Joint Logistic Support Force of PLA， Xiangyang， Hubei, ZENG Jitao   +3 more
doaj   +1 more source

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Journal of Experimental & Clinical Cancer Research, 2022
Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options.
Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella, Gianluigi Giannelli, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen, Katja Evert   +21 more
doaj   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]

, 2019
Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Eibl, Guido, Rozengurt, Enrique
core  

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer [PDF]

, 2016
Male breast cancer (MBC) is a rare disease and its biology is poorly understood. Deregulated Hippo pathway promotes oncogenic functions in female breast cancer.
Bardeesy, Bartsch, Bartsch, Basso, Bhargava, Brummelkamp, Cancer Genome Atlas Network, Chen, Cordenonsi, Costa, Daidone, De Maria, Del Sal, Di Fiore, Fjällskog, Fuchs, Guan, Gumbiner, Guénel, Hedenfalk, Hedenfalk, Ito, Jiang, Kuperwasser, Lakshmanaswamy, Lalloo, Lei, Lim, Little, Litwiniuk, Maugeri-Saccà, Maugeri-Saccà, Maugeri-Saccà, Palacios, Pan, Pan, Pan, Pan, Patrizii, Piccolo, Rosenberg, Rosenberg, Semenza, Semenza, Sergi, Speirs, Thomas, Thyss, van Diest, Winer, Wrana, Xu, Yurchenco   +52 more
core   +3 more sources

Colonic epithelium rejuvenation through YAP / TAZ [PDF]

The EMBO Journal, 2017
Stem cells are critical for normal tissue homeostasis and injury‐induced regeneration, but how wounding affects tissue regeneration at the cellular and molecular levels is not yet fully understood. A new study by Yui et al (2017) demonstrates that the extracellular matrix (ECM) remodeling modulates intestinal stem cells in tissue repair and ...
Rui Chen, Kun‐Liang Guan
openaire   +4 more sources

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source