Results 51 to 60 of about 24,096 (164)

Hypoxia promotes proliferation of alveolar epithelial cells by regulating chromatin H2A.Z deposition through TAZ-H2A.Z axis

陆军军医大学学报
Objective‍　‍To explore the role and underlying mechanism of the transcriptional coactivator with PDZ-binding motif (TAZ) and a histone variant of acute histone H2A (H2A.Z) in the repair of hypoxia-induced lung injury.
LIU Paiyu , LIU Paiyu , Department of Psychiatry and Psychology， No. 991 Hospital of Joint Logistic Support Force of PLA， Xiangyang， Hubei, ZENG Jitao   +3 more
doaj   +1 more source

A positive feedback loop between TAZ and miR-942-3p modulates proliferation, angiogenesis, epithelial-mesenchymal transition process, glycometabolism and ROS homeostasis in human bladder cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background Transcriptional coactivator with PDZ-binding motif (TAZ) has been reported to be involved in tumor progression, angiogenesis, epithelial-mesenchymal transition (EMT), glycometabolic modulation and reactive oxygen species (ROS) buildup. Herein,
Feifan Wang, Mengjing Fan, Xuejian Zhou, Yanlan Yu, Yueshu Cai, Hongshen Wu, Yan Zhang, Jiaxin Liu, Shihan Huang, Ning He, Zhenghui Hu, Guoqing Ding, Xiaodong Jin   +12 more
doaj   +1 more source

A Computational Model of YAP/TAZ Mechanosensing [PDF]

Biophysical Journal, 2016
19 pages, 7 pages supporting material, 4 figures, 4 supporting ...
Sun, Meng, Spill, Fabian, Zaman, Muhammad H.   +2 more
openaire   +3 more sources

Pharmacological activation of TAZ enhances osteogenic differentiation and bone formation of adipose-derived stem cells

Stem Cell Research & Therapy, 2018
Background Adipose-derived stem cells (ADSCs) are an attractive cell source for bone tissue engineering and have great potential for bone regeneration and defect repair.
Yumin Zhu, Yaping Wu, Jie Cheng, Qiong Wang, Zhongwu Li, Yanling Wang, Dongmiao Wang, Hua Wang, Weibing Zhang, Jinhai Ye, Hongbing Jiang, Lin Wang   +11 more
doaj   +1 more source

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human disease

Journal of Experimental & Clinical Cancer Research, 2022
Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options.
Antonio Cigliano, Shanshan Zhang, Silvia Ribback, Sara Steinmann, Marcella Sini, Cindy E. Ament, Kirsten Utpatel, Xinhua Song, Jingxiao Wang, Maria G. Pilo, Fabian Berger, Haichuan Wang, Junyan Tao, Xiaolei Li, Giovanni M. Pes, Serena Mancarella, Gianluigi Giannelli, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen, Katja Evert   +21 more
doaj   +1 more source

YAP/TAZ as therapeutic targets in cancer

Current Opinion in Pharmacology, 2016
The biology and regulation of YAP and TAZ, two closely related transcriptional regulators, are receiving increasing attention owing to their fundamental roles in organ growth, tissue repair and cancer. In particular, the widespread activation of YAP/TAZ in carcinomas, and the crucial role of YAP/TAZ activation for many 'hallmarks' of cancer are ...
Zanconato, Francesca, Battilana, Giusy, Cordenonsi, Michelangelo, Piccolo, Stefano   +3 more
openaire   +2 more sources

TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC

Blood Advances, 2019
: Multiple myeloma (MM) is an incurable blood cancer that is often characterized by amplification and overexpression of the MYC oncogene. Despite efforts, direct targeting of MYC is not yet possible; therefore, alternative strategies to inhibit MYC ...
Stacy Grieve, Gabriel Wajnberg, Miranda Lees, Simi Chacko, Jackson Weir, Nicolas Crapoulet, Tony Reiman   +6 more
doaj   +1 more source

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

Cell Reports, 2015
YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators downstream of the Hippo tumor-suppressor pathway. However, whether YAP and/or TAZ (YAP/TAZ) engage in transcriptional co-repression remains relatively unexplored.
Minchul Kim, Taekhoon Kim, Randy L. Johnson, Dae-Sik Lim   +3 more
doaj   +1 more source

YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts

Cell Communication and Signaling, 2018
Background Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact of YAP and TAZ levels on the TGF-β/
Zhaoping Qin, Wei Xia, Gary J. Fisher, John J. Voorhees, Taihao Quan   +4 more
doaj   +1 more source

DNA binding partners of YAP/TAZ

BMB Reports, 2018
Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ through MST1/2 and LATS1/2 pathway. It is also engaged in cross-talk with various other signaling pathways, including WNT, BMPs, Notch, GPCRs, and Hedgehog to further modulate ...
Kim, Min-Kyu, Jang, Ju-Won, Bae, Suk-Chul   +2 more
openaire   +3 more sources