Results 31 to 40 of about 24,287 (262)

The emerging roles of YAP and TAZ in cancer [PDF]

Nature Reviews Cancer, 2015
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the ...
Moroishi, Toshiro, Hansen, Carsten Gram, Guan, Kun-Liang   +2 more
openaire   +4 more sources

TAZ Regulates the Cisplatin Resistance of Epithelial Ovarian Cancer Cells via the ANGPTL4/SOX2 Axis

Analytical Cellular Pathology, 2022
Objective. Epithelial ovarian cancer (EOC) is a fatal gynecological malignancy. This study explored the mechanism of TAZ in regulating drug sensitivity of cisplatin (DDP-)-resistant EOC cells through the ANGPTL4/SOX2 axis. Methods.
Caihong Li, Qin Wang, Youzhen Luo, Juan Xiang   +3 more
doaj   +1 more source

TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves

eLife
Previously we showed that the hippo pathway transcriptional effectors, YAP and TAZ, are essential for Schwann cells (SCs) to develop, maintain and regenerate myelin . Although TEAD1 has been implicated as a partner transcription factor, the mechanisms by
Matthew Grove, Hyukmin Kim, Shuhuan Pang, Jose Paz Amaya, Guoqing Hu, Jiliang Zhou, Michel Lemay, Young-Jin Son   +7 more
doaj   +1 more source

YAP/TAZ functions and their regulation at a glance [PDF]

Journal of Cell Science, 2020
ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs, including the Hippo pathway. In the nucleus, they pair with DNA-binding factors of the TEAD family to regulate gene expression.
Arianna Pocaterra, Patrizia Romani, Sirio Dupont   +2 more
openaire   +2 more sources

Mechanobiology of YAP and TAZ in physiology and disease [PDF]

Nature Reviews Molecular Cell Biology, 2017
A growing body of evidence suggests that mechanical signals emanating from the cell's microenvironment are fundamental regulators of cell behaviour. Moreover, at the macroscopic scale, the influence of forces, such as the forces generated by blood flow, muscle contraction, gravity and overall tissue rigidity (for example, inside of a tumour lump), is ...
Panciera, Tito, Azzolin, Luca, Cordenonsi, Michelangelo, Piccolo, Stefano   +3 more
openaire   +2 more sources

YAP/TAZ: Molecular pathway and disease therapy

MedComm, 2023
The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism ...
Yuzi Wei, Victoria Lee Zhi Hui, Yilin Chen, Ruiying Han, Xianglong Han, Yongwen Guo   +5 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Devilish Effects of Taz in Nonalcoholic Steatohepatitis [PDF]

Cell Metabolism, 2016
Nonalcoholic steatohepatitis leads to cirrhosis and cancer in a rising number of patients with metabolic syndrome. In this issue of Cell Metabolism, Wang et al. (2016) identify the transcriptional co-activator Taz as a driver of inflammation and fibrosis through the induction of Indian hedgehog in hepatocytes, which stimulates fibrogenesis by hepatic ...
Scott L, Friedman, Youngmin A, Lee
openaire   +2 more sources

Research Advances in Targeting the YAP/TAZ Signaling Pathway 
to Improve Cancer Immunotherapy

Chinese Journal of Lung Cancer
Despite the groundbreaking advances in cancer immunotherapy achieved by immune checkpoint inhibitors (ICIs), their efficacy remains limited by the immunosuppressive tumor microenvironment (TME).
Pingxu ZHANG, Yiyi ZHAN
doaj   +1 more source

The political philosophy and ontology of autonomous zones

Интеллект. Инновации. Инвестиции
The article reveals the content of the Temporary Autonomous Zones’ conception (TAZ), proposed by the American anarchist thinker and poet Hakim Bey (real name – Peter Lamborn Wilson, 1945–2022) and rather poorly represented in Russian-language scientific ...
D. B. Polyakov
doaj   +1 more source