Results 31 to 40 of about 24,096 (164)
YAP and TAZ regulate cell volume [PDF]
Journal of Cell Biology, 2019 How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner. Here, using the fluorescence exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional ...
Nicolas A. Perez-Gonzalez +20 more
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Mechanisms of YAP/TAZ transcriptional control [PDF]
Cell Stress, 2021 Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor microenvironment.
Battilana G., Zanconato F., Piccolo S.
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eLifePreviously we showed that the hippo pathway transcriptional effectors, YAP and TAZ, are essential for Schwann cells (SCs) to develop, maintain and regenerate myelin . Although TEAD1 has been implicated as a partner transcription factor, the mechanisms by
Matthew Grove +7 more
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TAZ Regulates the Cisplatin Resistance of Epithelial Ovarian Cancer Cells via the ANGPTL4/SOX2 Axis
Analytical Cellular Pathology, 2022 Objective. Epithelial ovarian cancer (EOC) is a fatal gynecological malignancy. This study explored the mechanism of TAZ in regulating drug sensitivity of cisplatin (DDP-)-resistant EOC cells through the ANGPTL4/SOX2 axis. Methods.
Caihong Li +3 more
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Research Advances in Targeting the YAP/TAZ Signaling Pathway to Improve Cancer Immunotherapy
Chinese Journal of Lung CancerDespite the groundbreaking advances in cancer immunotherapy achieved by immune checkpoint inhibitors (ICIs), their efficacy remains limited by the immunosuppressive tumor microenvironment (TME).
Pingxu ZHANG, Yiyi ZHAN
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The political philosophy and ontology of autonomous zones
Интеллект. Инновации. ИнвестицииThe article reveals the content of the Temporary Autonomous Zones’ conception (TAZ), proposed by the American anarchist thinker and poet Hakim Bey (real name – Peter Lamborn Wilson, 1945–2022) and rather poorly represented in Russian-language scientific ...
D. B. Polyakov
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International Journal of Nanomedicine, 2021 Penghui Hu,1,2,* Qian Gao,1,2,* Huimin Zheng,1,2 Yujuan Tian,1,2 Guoying Zheng,1 Xiaoyu Yao,1 Junjiang Zhang,1 Xudong Wu,2 Lei Sui1 1Department of Prosthodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin, People’s ...
Hu P +8 more
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YAP/TAZ: Molecular pathway and disease therapy
MedComm, 2023 The Yes‐associated protein and its transcriptional coactivator with PDZ‐binding motif (YAP/TAZ) are two homologous transcriptional coactivators that lie at the center of a key regulatory network of Hippo, Wnt, GPCR, estrogen, mechanical, and metabolism ...
Yuzi Wei +5 more
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YAP/TAZ functions and their regulation at a glance [PDF]
Journal of Cell Science, 2020 ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs, including the Hippo pathway. In the nucleus, they pair with DNA-binding factors of the TEAD family to regulate gene expression.
Arianna Pocaterra +2 more
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YAP/TAZ: An epitome of tumorigenesis
Cancer LettersMounting evidence has demonstrated that the transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), are the main effectors of the Hippo signal transduction pathway that is involved in multiple layered events in tumorigenesis.
Soumya Mukherjee +2 more
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