Results 21 to 30 of about 104,199 (294)

MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation [PDF]

, 2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used.
Alessandro, Riccardo, Bellavia, Daniele, Carina, Valeria, Conigliaro, Alice, Costa, Viviana, De Luca, Angela, Fini, Milena, Giavaresi, Gianluca, Raimondi, Lavinia, Salamanna, Francesca   +9 more
core   +1 more source

Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease

Cells, 2020
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces.
Mathias Cobbaut, Simge Karagil, Lucrezia Bruno, Maria Del Carmen Diaz de la Loza, Francesca E Mackenzie, Michael Stolinski, Ahmed Elbediwy   +6 more
doaj   +1 more source

Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs

Drug Design, Development and Therapy, 2022
Yajing Fu,1 Dan Ma,2 Fengyan Fan,3 Tongke Sun,1 Ruiqi Han,1 Yanran Yang,1 Jun Zhang1 1Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration ...
Fu Y, Ma D, Fan F, Sun T, Han R, Yang Y, Zhang J   +6 more
doaj  

YAP and TAZ regulate cell volume [PDF]

Journal of Cell Biology, 2019
How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner. Here, using the fluorescence exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional ...
Nicolas A. Perez-Gonzalez, Nash D. Rochman, Kai Yao, Jiaxiang Tao, Minh-Tam Tran Le, Shannon Flanary, Lucia Sablich, Ben Toler, Eliana Crentsil, Felipe Takaesu, Bram Lambrus, Jessie Huang, Vivian Fu, Pragati Chengappa, Tia M. Jones, Andrew J. Holland, Steven An, Denis Wirtz, Ryan J. Petrie, Kun-Liang Guan, Sean X. Sun   +20 more
openaire   +4 more sources

Drug-Resistant Breast Cancer: Dwelling the Hippo Pathway to Manage the Treatment

Breast Cancer: Targets and Therapy, 2021
Simran Kaur,1 Mohammad Zeeshan Najm,1 Mohammad Aasif Khan,2 Naseem Akhter,3 Vyas M Shingatgeri,1 Mudra Sikenis,1 Sadaf,4 Abdulaziz A Aloliqi5 1School of Bioscience, Apeejay Stya University, Gurugram, Haryana, India; 2Department of Biosciences, Jamia ...
Kaur S, Najm MZ, Khan MA, Akhter N, Shingatgeri VM, Sikenis M, Sadaf, Aloliqi AA   +7 more
doaj  

TAZ is required for chondrogenesis and skeletal development

Cell Discovery, 2021
Chondrogenesis is a major contributor to skeletal development and maintenance, as well as bone repair. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key regulator of osteogenesis and adipogenesis, but how TAZ regulates chondrogenesis and ...
Yang Li, Shuting Yang, Ling Qin, Shuying Yang   +3 more
doaj   +1 more source

The Hippo Transducer YAP/TAZ as a Biomarker of Therapeutic Response and Prognosis in Trastuzumab-Based Neoadjuvant Therapy Treated HER2-Positive Breast Cancer Patients

Frontiers in Pharmacology, 2020
BackgroundWe explored the therapeutic and prognostic effect of YAP/TAZ intensityinHER2-positive breast cancer patients. We also investigated the relationship between YAP/TAZ expression and Trastuzumab-resistance.MethodsWe collected clinicopathological ...
Jia-qi Yuan, Nian-hua Ding, Zhi Xiao
doaj   +1 more source

TAZ Suppresses NFAT5 Activity through Tyrosine Phosphorylation [PDF]

, 2014
Transcriptional coactivator with PDZ-binding motif (TAZ) physically interacts with a variety of transcription factors and modulates their activities involved in cell proliferation and mesenchymal stem cell differentiation.
Han, Ki Hwan, Hong, Jeong-Ho, Hwang, Eun Sook, Jang, Eun Jung, Jeong, Hana, Kwon, H. Moo   +5 more
core   +1 more source

Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Forum of Clinical Oncology, 2019
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios, Zakopoulou Roubini, Zagouri Flora, Bamias Aristotelis, Dimopoulos Meletios Athanasios   +4 more
doaj   +1 more source

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse HepatocarcinogenesisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Yes-associated protein (YAP) and its paralog transcriptional co-activator with post synaptic density protein, drosophila disc large tumor suppressor and zonula occludens-1-binding motif (TAZ) are 2 co-activators downstream of Hippo
Haichuan Wang, Jingxiao Wang, Shanshan Zhang, Jiaoyuan Jia, Xianqiong Liu, Jie Zhang, Pan Wang, Xinhua Song, Li Che, Ke Liu, Silvia Ribback, Antonio Cigliano, Matthias Evert, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen   +16 more
doaj   +1 more source