Results 21 to 30 of about 24,287 (262)

Role of TAZ as Mediator of Wnt Signaling [PDF]

Cell, 2012
Wnt growth factors are fundamental regulators of cell fate, but how the Wnt signal is translated into biological responses is incompletely understood. Here, we report that TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/β-catenin cascade.
AZZOLIN, LUCA, ZANCONATO, FRANCESCA, BRESOLIN, SILVIA, Forcato M., BASSO, GIUSEPPE, BICCIATO, SILVIO, CORDENONSI, MICHELANGELO, PICCOLO, STEFANO   +7 more
openaire   +4 more sources

Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs

Drug Design, Development and Therapy, 2022
Yajing Fu,1 Dan Ma,2 Fengyan Fan,3 Tongke Sun,1 Ruiqi Han,1 Yanran Yang,1 Jun Zhang1 1Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration ...
Fu Y, Ma D, Fan F, Sun T, Han R, Yang Y, Zhang J   +6 more
doaj  

Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells.

PLoS ONE, 2020
Transcriptional co-activator with PDZ-binding motif (TAZ) plays versatile roles in the regulation of cell proliferation and differentiation. TAZ activity changes in response to the cellular environment such as mechanic and nutritional stimuli, osmolarity,
Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa, Takuya Oyaizu, Naoki Yamamoto, Mari Ishigami-Yuasa, Nozomi Tsuemoto, Shigeru Ito, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata   +17 more
doaj   +1 more source

Drug-Resistant Breast Cancer: Dwelling the Hippo Pathway to Manage the Treatment

Breast Cancer: Targets and Therapy, 2021
Simran Kaur,1 Mohammad Zeeshan Najm,1 Mohammad Aasif Khan,2 Naseem Akhter,3 Vyas M Shingatgeri,1 Mudra Sikenis,1 Sadaf,4 Abdulaziz A Aloliqi5 1School of Bioscience, Apeejay Stya University, Gurugram, Haryana, India; 2Department of Biosciences, Jamia ...
Kaur S, Najm MZ, Khan MA, Akhter N, Shingatgeri VM, Sikenis M, Sadaf, Aloliqi AA   +7 more
doaj  

Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease

Cells, 2020
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces.
Mathias Cobbaut, Simge Karagil, Lucrezia Bruno, Maria Del Carmen Diaz de la Loza, Francesca E Mackenzie, Michael Stolinski, Ahmed Elbediwy   +6 more
doaj   +1 more source

Mechanisms of YAP/TAZ transcriptional control [PDF]

Cell Stress, 2021
Dysregulated gene expression is intrinsic to cell transformation, tumorigenesis and metastasis. Cancer-specific gene-expression profiles stem from gene regulatory networks fueled by genetic and epigenetic defects, and by abnormal signals of the tumor microenvironment.
Battilana G., Zanconato F., Piccolo S.
openaire   +4 more sources

Clinical and biological implications of Hippo pathway dysregulation in sarcomas

Forum of Clinical Oncology, 2019
Sarcomas are mesenchymal malignant tumors with poor prognosis and limited treatment options. Hippo pathway is a recently discovered pathway normally involved in organ development and wound healing. Hippo signaling is often altered in solid tumors.
Kyriazoglou Anastasios, Zakopoulou Roubini, Zagouri Flora, Bamias Aristotelis, Dimopoulos Meletios Athanasios   +4 more
doaj   +1 more source

LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer

Cell Death Discovery, 2021
Long non-coding RNAs (lncRNAs) regulate numerous biological processes involved in both development and carcinogenesis. Hippo-YAP/TAZ signaling, a critical pathway responsible for organ size control, is often dysregulated in a variety of cancers. However,
Bowen Zhu, Megan Finch-Edmondson, Kim Whye Leong, Xiaoqian Zhang, Mitheera V., Quy Xiao Xuan Lin, Yaelim Lee, Wei Ting Ng, Huili Guo, Yue Wan, Marius Sudol, Ramanuj DasGupta   +11 more
doaj   +1 more source

Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse HepatocarcinogenesisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Yes-associated protein (YAP) and its paralog transcriptional co-activator with post synaptic density protein, drosophila disc large tumor suppressor and zonula occludens-1-binding motif (TAZ) are 2 co-activators downstream of Hippo
Haichuan Wang, Jingxiao Wang, Shanshan Zhang, Jiaoyuan Jia, Xianqiong Liu, Jie Zhang, Pan Wang, Xinhua Song, Li Che, Ke Liu, Silvia Ribback, Antonio Cigliano, Matthias Evert, Hong Wu, Diego F. Calvisi, Yong Zeng, Xin Chen   +16 more
doaj   +1 more source

YAP and TAZ regulate cell volume [PDF]

Journal of Cell Biology, 2019
How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner. Here, using the fluorescence exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional ...
Nicolas A. Perez-Gonzalez, Nash D. Rochman, Kai Yao, Jiaxiang Tao, Minh-Tam Tran Le, Shannon Flanary, Lucia Sablich, Ben Toler, Eliana Crentsil, Felipe Takaesu, Bram Lambrus, Jessie Huang, Vivian Fu, Pragati Chengappa, Tia M. Jones, Andrew J. Holland, Steven An, Denis Wirtz, Ryan J. Petrie, Kun-Liang Guan, Sean X. Sun   +20 more
openaire   +4 more sources