Results 91 to 100 of about 67,151 (262)

PML Surfs into HIPPO Tumor Suppressor Pathway [PDF]

Frontiers in Oncology, 2013
Growth arrest, inhibition of cell proliferation, apoptosis, senescence, and differentiation are the most characterized effects of a given tumor suppressor response. It is becoming increasingly clear that tumor suppression results from the integrated and synergistic activities of different pathways.
Sabrina eStrano, Francesca eFausti, Silvia eDi Agostino, Marius eSudol, Marius eSudol, Giovanni eBlandino   +5 more
openaire   +3 more sources

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1KO mice

Clinical and Translational Medicine
Introduction Nephronophthisis (NPH) is an autosomal recessive interstitial cystic kidney disease, which is the most common genetic cause of end‐stage renal disease (ESRD) in childhood.
Yichen Yang, Zhihe Xue, Jiayong Lai, Jinglan Zhang, Changmiao Pang, Jinglin Zhong, Zhanpeng Kuang, Baojuan Zou, Yaqing Liu, Liangzhong Sun   +9 more
doaj   +1 more source

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.

PLoS Genetics, 2016
Hippo signaling acts as a master regulatory pathway controlling growth, proliferation, and apoptosis and also ensures that variations in proliferation do not alter organ size.
Maryam Jahanshahi, Kuangfu Hsiao, Andreas Jenny, Cathie M Pfleger   +3 more
doaj   +1 more source

The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth

Biology Open, 2013
Summary The Hippo pathway has a central role in coordinating tissue growth and apoptosis. Mutations that compromise Hippo pathway activity cause tissue overgrowth and have been causally linked to cancer.
Wei Zhang, Stephen M. Cohen
doaj   +1 more source

LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer [PDF]

, 2019
Cancer stem cells (CSCs), which play important roles in tumor initiation and progression, are resistant to many types of therapies. However, the regulatory mechanisms underlying CSC-specific properties, including self-renewal, are poorly understood. Here,
Fukushima, Kohshiro, Fukuzawa, Moe, Longmore, Gregory D, Mukai, Satomi, Naito, Yoko, Nojima, Hiroshi, Nozaki, Masami, Okamoto, Ayumi, Sasakura, Towa, Yabuta, Norikazu   +9 more
core   +1 more source

Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]

, 2019
The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe, Sievers, Laura Katharina   +1 more
core   +2 more sources

RAP2 mediates mechanoresponses of the Hippo pathway [PDF]

Nature, 2018
Mammalian cells are surrounded by neighbouring cells and extracellular matrix (ECM), which provide cells with structural support and mechanical cues that influence diverse biological processes1. The Hippo pathway effectors YAP (also known as YAP1) and TAZ (also known as WWTR1) are regulated by mechanical cues and mediate cellular responses to ECM ...
Meng, Zhipeng, Qiu, Yunjiang, Lin, Kimberly C, Kumar, Aditya, Placone, Jesse K, Fang, Cao, Wang, Kuei-Chun, Lu, Shicong, Pan, Margaret, Hong, Audrey W, Moroishi, Toshiro, Luo, Min, Plouffe, Steven W, Diao, Yarui, Ye, Zhen, Park, Hyun Woo, Wang, Xiaoqiong, Yu, Fa-Xing, Chien, Shu, Wang, Cun-Yu, Ren, Bing, Engler, Adam J, Guan, Kun-Liang   +22 more
openaire   +4 more sources

A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post‐Acute Phase Wound Healing

Advanced Healthcare Materials, EarlyView.
This review examines how in vitro electrical and mechanical stimulation modulates wound healing in fibroblasts and keratinocytes. Analyzing over 560 experimental data points, we relate stimulation parameters to proliferation and migration outcomes, evaluate platform designs, and highlight the need for multi‐parameter optimization to advance targeted ...
Matthew K. Burgess, Ellen F. Marsh, Veronica M. Lucian, Malavika Nair   +3 more
wiley   +1 more source

Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis

Nature Communications
The Hippo pathway controls developmental, homeostatic and regenerative tissue growth, and is frequently dysregulated in various diseases. Although this pathway can be activated by innate immune/inflammatory stimuli, the underlying mechanism is not fully ...
Yinan Yang, Huijing Zhou, Xiawei Huang, Chengfang Wu, Kewei Zheng, Jingrong Deng, Yonggang Zheng, Jiahui Wang, Xiaofeng Chi, Xianjue Ma, Huimin Pan, Rui Shen, Duojia Pan, Bo Liu   +13 more
doaj   +1 more source